...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Fat and Expanded act in parallel to regulate growth through Warts
【24h】

Fat and Expanded act in parallel to regulate growth through Warts

机译：脂肪和膨胀同时作用于疣

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The conserved Drosophila tumor suppressors Fat and Expanded have both recently been implicated in regulating the activity of the Warts tumor suppressor. However, there has been disagreement as to the nature of the links among Fat, Expanded, and Warts and the significance of these links to growth control. We report here that mutations in either expanded or fat can be rescued to viability simply by overexpressing Warts, indicating that their essential function is their influence on Warts rather than reported effects on endocytosis or other pathways. These rescue experiments also separate the transcriptional from the planar cell polarity branches of Fat signaling and reveal that Expanded does not directly affect polarity. We also investigate the relationship between expanded and fat and show, contrary to prior reports, that they have additive effects on imaginal disk growth and development. Although mutation of fat can cause partial loss of Expanded protein from the membrane, mutation of fat promotes growth even when Expanded is overexpressed and accumulates at its normal subapical location. These observations argue against recent proposals that Fat acts simply as a receptor for the Hippo signaling pathway and instead support the proposal that Fat and Expanded can act in parallel to regulate Warts through distinct mechanisms.
机译：保守的果蝇肿瘤抑制因子脂肪和膨胀都最近与调节疣肿瘤抑制因子的活性有关。但是，关于脂肪，膨大和疣之间的联系的性质以及这些联系对增长控制的重要性一直存在分歧。我们在此报告，仅通过过度表达疣即可将扩增的或脂肪中的突变挽救到生存力，这表明它们的基本功能是对疣的影响，而不是对胞吞作用或其他途径的影响。这些抢救实验还从脂肪信号的平面细胞极性分支中分离出转录，并揭示了扩展不会直接影响极性。我们还研究了膨化与脂肪之间的关系，并显示出与先前的报道相反的事实，即它们对虚拟盘的生长和发育具有累加作用。尽管脂肪的突变会引起扩张的蛋白质从膜上部分丢失，但是即使脂肪的过度表达并累积在其正常的根尖下，脂肪的突变也会促进生长。这些发现与最近提出的关于脂肪仅充当河马信号传导途径的受体的提议相抵触，相反，该提议支持脂肪和膨胀可以通过不同的机制并行调节疣的提议。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号