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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >In This Issue
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In This Issue

机译：在这个问题上

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One route to apoptosis, or cell death, begins as death-inducing signals prompt the mitochondria to release cytochrome c. Cytoso-lic cytochrome c then binds Apaf-1, which triggers a cascade of molecular interactions that leads to the cell's death. However, brain tumors are often resistant to chemotherapeutic agents, which trigger cell death at a step upstream of cytochrome c release. Carrie Johnson et al. show that directly activating the apoptosis pathway with cytochrome c causes apoptosis in murine astrocytomas and medulloblastomas but does not harm normal brain tissue. The authors show that primary neurons within the cerebellum and cortex are resistant to cytosolic cytochrome c-induced cell death. They report that this differential sensitivity is due to high Apaf-1 levels in tumor tissue versus low Apaf-1 levels in surrounding brain tissue. Johnson et al. suggest that this finding could be exploited to selectively kill brain cancer cells.
机译：细胞凋亡或细胞死亡的一种途径是从诱导死亡的信号促使线粒体释放细胞色素c开始。然后，细胞溶质细胞色素c结合Apaf-1，从而触发一系列分子相互作用，从而导致细胞死亡。然而，脑肿瘤通常对化学治疗剂具有抗性，化学治疗剂在细胞色素C释放的上游触发细胞死亡。嘉莉·约翰逊（Carrie Johnson）等人。表明用细胞色素c直接激活细胞凋亡途径可引起鼠星形细胞瘤和髓母细胞瘤的细胞凋亡，但不会损害正常脑组织。作者表明，小脑和皮层内的初级神经元对胞质细胞色素c诱导的细胞死亡具有抗性。他们报告说，这种差异敏感性是由于肿瘤组织中的高Apaf-1水平相对于周围脑组织中的低Apaf-1水平所致。约翰逊等。提示该发现可用于选择性杀死脑癌细胞。

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