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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Chemosensing in Escherichia coli: Two regimes of two-state receptors
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Chemosensing in Escherichia coli: Two regimes of two-state receptors

机译:大肠杆菌中的化学传感:两种状态受体的两种方案

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The chemotaxis network in Escherichia coli is remarkable for its sensitivity to small relative changes in the concentrations of multiple chemical signals. We present a model for signal integration by mixed clusters of interacting two-state chemoreceptors. Our model results compare favorably to the results obtained by Sourjik and Berg with in vivo fluorescence resonance energy transfer. Importantly, we identify two distinct regimes of behavior, depending on the relative energies of the two states of the receptors. In regime Ⅰ, coupling of receptors leads to high sensitivity, while in regime Ⅱ, coupling of receptors leads to high cooperativity, i.e., high Hill coefficient. For homogeneous receptors, we predict an observable transition between regime Ⅰ and regime Ⅱ with increasing receptor methylation or amidation.
机译:大肠杆菌的趋化性网络以其对多种化学信号浓度的较小相对变化的敏感性而著称。我们提出了一种由相互作用的两态化学感受器的混合簇进行信号整合的模型。我们的模型结果与Sourjik和Berg通过体内荧光共振能量转移获得的结果相比具有优势。重要的是,我们根据受体两种状态的相对能量确定了两种不同的行为方式。在方案Ⅰ中,受体的耦合导致高灵敏度,而在方案Ⅱ中,受体的耦合导致高协同性,即高希尔系数。对于同质受体,我们预测随着受体甲基化或酰胺化的增加,方案Ⅰ和方案Ⅱ之间可观察到过渡。

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