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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Retinoic acid is required early during adult neurogenesis in the dentate gyrus
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Retinoic acid is required early during adult neurogenesis in the dentate gyrus

机译：在齿状回的成年神经发生的早期，需要维甲酸

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摘要

Retinoic acid (RA) is commonly used in vitro to differentiate stem cell populations including adult neural stem cells into neurons; however, the in vivo function of RA during adult neurogenesis remains largely unexplored. We found that depletion of RA in adult mice leads to significantly decreased neuronal differentiation within the granular cell layer of the dentate gyrus. RA contribution to neurogenesis occurs early, for RA deficiency also results in a decrease in newborn cells expressing an immature neuronal marker. Furthermore, although proliferation is unaffected during RA absence, cell survival is significantly reduced. Finally, a screen for retinoid-induced genes identifies metabolic targets including the lipid transporters, CD-36 and ABCA-1, the lipogenic master regulator SREIBP1c as well as components of the Writ signaling pathway. Our results reveal RA as a crucial contributor to early stages of adult neurogenesis and survival in vivo.
机译：视黄酸（RA）通常在体外用于将干细胞群体（包括成年神经干细胞）分化为神经元。然而，在成年神经发生过程中，RA的体内功能仍未开发。我们发现成年小鼠的RA耗竭导致齿状回的颗粒细胞层内神经元分化明显减少。 RA对神经发生的贡献较早发生，因为RA缺乏还导致表达未成熟神经元标记物的新生细胞减少。此外，尽管在RA缺失期间增殖不受影响，但是细胞存活率显着降低。最后，对类维生素A诱导基因的筛选可识别代谢靶标，包括脂质转运蛋白，CD-36和ABCA-1，生脂主调节剂SREIBP1c以及Writ信号通路的组成部分。我们的结果表明，RA是成人神经发生早期和体内存活的关键因素。

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