...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport
【24h】

Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport

机译：肺泡I型细胞中的功能性离子通道支持I型细胞在肺离子转运中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Efficient gas exchange in the lungs depends on regulation of the amount of fluid in the thin (average 0.2 mu m) liquid layer lining the alveolar epithelium. Fluid fluxes are regulated by ion transport across the alveolar epithelium, which is composed of alveolar type I (TI) and type II (TII) cells. The accepted paradigm has been that TII cells, which cover < 5% of the internal surface area of the lung, transport Na+ and Cl- and that TI cells, which cover > 95% of the surface area, provide a route for water absorption. Here we present data that TI cells contain functional epithelial Na+ channels (ENaC), pimozide-sensitive cation channels, K+ channels, and the cystic fibrosis transmembrane regulator. Till cells contain ENaC and cystic fibrosis transmembrane regulator, but few pimozide-sensitive cation channels. These findings lead to a revised paradigm of ion and water transport in the lung in which (i) Na+ and Cl- transport occurs across the entire alveolar epithelium (TI and TII cells) rather than only across TII cells; and (h) by virtue of their very large surface area, TI cells are responsible for the bulk of transepithelial Na+ transport in the lung.
机译：肺中有效的气体交换取决于对肺泡上皮内衬的薄（平均0.2微米）液体层中液体量的调节。离子流通过肺泡上皮细胞（由I型（TI）和II型（TII）细胞）组成的离子运输调节流体通量。公认的范例是，覆盖肺内表面积小于5％的TII细胞运输Na +和Cl-，覆盖肺内表面积超过95％的TI细胞提供了吸水途径。在这里，我们提出的数据表明，TI细胞包含功能性上皮Na +通道（ENaC），对匹莫齐特敏感的阳离子通道，K +通道和囊性纤维化跨膜调节剂。直到细胞包含ENaC和囊性纤维化跨膜调节剂，但很少有对pimozide敏感的阳离子通道。这些发现导致了肺中离子和水的运输模式发生了改变，其中（i）Na +和Cl-运输发生在整个肺泡上皮（TI和TII细胞）上，而不是仅发生在TII细胞上。 （h）由于TI细胞非常大的表面积，它们负责肺中大量的上皮Na +转运。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号