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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC
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LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC

机译：LHP1，杂色氨酸蛋白1的拟南芥同源物，是FLC的表观遗传沉默所必需的

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摘要

Vernalization is the acceleration of flowering by prolonged cold that aligns the onset of reproductive development with spring conditions. A key step of vernalization in Arabidopsis is the epigenetic silencing of FLOWERING LOCUS C (FLC), which encodes a repressor of flowering. The vernalization-induced epigenetic silencing of FLC is associated with histone deacetylation and H3K27me2 and H3K9me2 methylation mediated by VRN/VIN proteins. We have analyzed whether different histone methyltransferases and the chromodomain protein LIKE HETEROCHROMATIN PROTEIN (LHP)1 might play a role in vernalization. No single loss-of-function mutation in the histone methyltransferases studied disrupted the vernalization response; however, Ihp1 mutants revealed a role for LHP1 in maintaining epigenetic silencing of FLC. Like LHP1, VRN1 functions in both flowering-time control and vernalization. We explored the localization of VRN1 and found it to be associated generally with Arabidopsis chromosomes but not the heterochromatic chromocenters. This association did not depend on vernalization or VRN2 function and was maintained during mitosis but was lost in meiotic chromosomes, suggesting that VRN1 may contribute to chromatin silencing that is not meiotically stable.
机译：春化是长时间的寒冷使开花加速，使生殖发育与春季条件相吻合。在拟南芥中进行春化处理的关键步骤是将花的形成因子C（FLC）的表观遗传沉默。春化诱导的FLC表观遗传沉默与VRN / VIN蛋白介导的组蛋白去乙酰化以及H3K27me2和H3K9me2甲基化有关。我们已经分析了不同的组蛋白甲基转移酶和色域蛋白LIKE异染色质蛋白（LHP）1是否可能在春化过程中起作用。在研究的组蛋白甲基转移酶中没有单一的功能丧失突变会破坏春化反应。然而，Ihp1突变体揭示了LHP1在维持FLC的表观遗传沉默中的作用。像LHP1一样，VRN1在开花时间控制和春化中均起作用。我们探索了VRN1的定位，发现它通常与拟南芥染色体相关，但与异色染色体中心无关。该关联不依赖于春化处理或VRN2功能，在有丝分裂过程中得以维持，但在减数分裂染色体中丢失，这表明VRN1可能导致染色质沉默（减数分裂不稳定）。

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