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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle
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The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle

机译：发情周期调节边缘前脑中时钟蛋白PER2的表达

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摘要

Daily behavioral and physiological rhythms are linked to circadian oscillations of clock genes in the brain and periphery that are synchronized by the master clock in the suprachiasimatic nucleus. in addition, there are a number of inputs that can influence circadian oscillations in clock gene expression in a tissue-specific manner. Here we identify an influence on the circadian oscillation of the clock protein PER2, endogenous changes in ovarian steroids, within two nuclei of the limbic forebrain: the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala. We show that the daily rhythm of PER2 expression within these nuclei but not in the suprachiasmatic nucleus, dentate gyrus, or basolateral amygdala is blunted in the metestrus and diestrus phases of the estrus cycle. The blunting of the PER2 rhythm at these phases of the cycle is abolished by ovariectomy and restored by phasic estrogen replacement suggesting that fluctuations in estrogen levels or their sequelae are necessary to produce these effects. The finding that fluctuations in ovarian hormones have area-specific effects on clock gene expression in the brain introduces a new level of organizational complexity in the control of circadian rhythms of behavior and physiology.
机译：日常的行为和生理节律与大脑和周围的时钟基因的昼夜节律振荡有关，这些时钟基因由上视准核中的主时钟同步。另外，有许多输入可以以组织特异性方式影响时钟基因表达的昼夜节律振荡。在这里，我们确定对时钟蛋白PER2的昼夜节律振荡的影响，卵巢类固醇的内源性变化，在边缘前脑的两个核内：纹状体末梢的床核的椭圆形核和杏仁核的中核。我们显示，在这些核中而不是在视交叉上核，齿状回或基底外侧扁桃体中，PER2表达的日常节律在发情周期的肠die和发情期变钝。卵巢切除术消除了周期中这些阶段的PER2节律的钝化，并通过阶段性雌激素替代恢复了PER2的节律，这表明产生这些作用所必需的雌激素水平或其后遗症的波动。卵巢激素的波动对大脑中的时钟基因表达具有特定区域影响的发现为控制行为和生理的昼夜节律带来了组织复杂性的新水平。

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