...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >How TRIM5α defends against retroviral invasions
【24h】

How TRIM5α defends against retroviral invasions

机译：TRIM5α如何防御逆转录病毒入侵

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The immune response to viral infections comes in two well described flavors. First, innate immunity [for example, natural killer (NK) cells and IFN responses] nonspecifically recognizes viral infections to trigger autocrine and paracrine signals that limit viral replication. Second, adaptive immunity (for example, T cells and B cells) specifically recognizes viral infections through secreted and cell-meditated factors. However, for retroviral infections, there is a third component of viral recognition and subsequent restriction that has been called "intrinsic immunity" (1). Intrinsic immunity differs from innate and adaptive immunity in that it is cell autonomous (does not rely on secreted factors), it is present in many cells (rather than only in specialized immune cells), it does not need to be induced by viral infections, and it probably evolves with viral infections on a longer evolutionary time scale than the innate and adaptive immune responses. Trim5α is a cytoplasmic protein that forms part of the intrinsic immune system that restricts retroviral infections in primates. This protein targets the viral capsid (CA) protein in a species-specific manner, but the mechanism of how Trim5α inhibits retroviral infections has been unclear. In this issue of PNAS, Stremlau et al. (2) address this important question by showing that Trim5α from rhesus macaques inhibits HIV type 1 (HIV-1) by direct recognition of the viral capsid protein followed by accelerated "uncoating" of capsid from the incoming viral particle.
机译：对病毒感染的免疫反应有两种很好描述的风味。首先，先天免疫[例如，自然杀伤（NK）细胞和IFN反应]非特异性地识别病毒感染，从而触发限制病毒复制的自分泌和旁分泌信号。其次，适应性免疫（例如T细胞和B细胞）通过分泌的和细胞冥想的因子特异性识别病毒感染。但是，对于逆转录病毒感染，病毒识别的第三部分和随后的限制被称为“内在免疫”（1）。本质免疫不同于先天免疫和适应性免疫，因为它是细胞自主的（不依赖分泌因子），它存在于许多细胞中（而不仅是专门的免疫细胞中），不需要被病毒感染诱导，与病毒感染相比，它可能比先天性和适应性免疫应答在更长的进化时间尺度上进化。 Trim5α是一种细胞质蛋白，形成了固有免疫系统的一部分，该免疫系统限制了灵长类动物的逆转录病毒感染。该蛋白以物种特异性方式靶向病毒衣壳（CA）蛋白，但Trim5α如何抑制逆转录病毒感染的机制尚不清楚。在本期PNAS中，Stremlau等人。 （2）通过显示恒河猴的Trim5α通过直接识别病毒衣壳蛋白，然后从进入的病毒颗粒中加速衣壳“脱壳”，抑制了猕猴的Trim5α抑制HIV 1型（HIV-1）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号