Nick Cozzarelli and I were born in the same year, and we both started working on DNA replication in the late 1960s. For nearly 30 years, Nick's laboratory focused on understanding the effects of DNA topology on biological processes (and vice versa). Demonstrating remarkable persistence and insight, he was able to develop this complex area of research into an incredibly rich and complex field—one that yielded astonishing biological insights in ways that I never thought possible (1-4).
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