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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila
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Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila

机译：三聚体G蛋白Go在果蝇不对称细胞分裂中的双重作用

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摘要

During asymmetric division, a cell polarizes and differentially distributes components to its opposite ends. The subsequent division differentially segregates the two component pools to the daughters, which thereby inherit different developmental directives. In Drosophila sensory organ precursor cells, the localization of Numb protein to the cell's anterior cortex is a key patterning event and is achieved by the combined action of many proteins, including Pins, which itself is localized anteriorly. Here, a role is described for the trimeric G protein Go in the anterior localization of Numb and daughter cell fate specification. Go is shown to interact with Pins. In addition to a role in recruiting Numb to an asymmetric location in the cell's cortex, Go transduces a signal from the Frizzled receptor that directs the position in which the complex forms. Thus, Go likely integrates the signaling that directs the formation of the complex with the signaling that directs where the complex forms.
机译：在不对称分裂过程中，细胞会极化并将组分差异分布到其相对端。随后的划分​​将两个组件池有区别地隔离到子组件，从而继承了不同的开发指令。在果蝇的感觉器官前体细胞中，Numb蛋白在细胞前皮质的定位是一个关键的模式事件，并且是通过包括Pins在内的许多蛋白质的联合作用而实现的，而Pins本身就位于前面。在这里，描述了三聚体G蛋白Go在Numb和子代细胞命运特征的前部定位中的作用。显示Go与Pins互动。除了在将Numb募集到细胞皮层的不对称位置中发挥作用外，Go还转导了来自卷曲蛋白受体的信号，该信号指导复合物的形成位置。因此，Go可能将引导复合物形成的信号与引导复合物形成的信号整合在一起。

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