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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction
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Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction

机译：控制T细胞受体-MHC-I相互作用的不同热力学暗示了外部因素指导MHC限制

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摘要

The underlying basis of major histocompatibility complex (MHC) restriction is unclear. Nevertheless, current data suggest that a common thermodynamic signature dictates alpha beta T cell receptor (TcR) ligation. To evaluate whether this thermodynamic signature defines MIHC restriction, we have examined the thermodynamic basis of a highly characterized immunodominant TcR interacting with its cognate peptide-MHC-I ligand. Surprisingly, we observed this interaction to be governed by favorable enthalpic and entropic forces, which is in contrast to the prevailing generality, namely, enthalpically driven interactions combined with markedly unfavorable entropic forces. We conclude that extrinsic molecular factors, such as coreceptor ligation, conformational adjustments involved in TcR signaling, or constraints dictated by higher-order arrangement of ligated TcRs, might play a greater role in guiding MHC restriction than appreciated previously.
机译：主要组织相容性复合物（MHC）限制的根本基础尚不清楚。尽管如此，当前数据表明常见的热力学特征决定了αβT细胞受体（TcR）的连接。为了评估此热力学特征是否定义了MIHC限制，我们已经检查了高度表征的免疫优势TcR及其同源肽-MHC-1配体相互作用的热力学基础。出乎意料的是，我们观察到这种相互作用受有利的焓和熵力支配，这与普遍的普遍性相反，即，由焓驱动的相互作用与明显不利的熵力相结合。我们得出的结论是，外在分子因素，例如共受体连接，参与TcR信号的构象调整，或由连接TcR的高阶排列所决定的限制，可能在指导MHC限制中起着比以前所认识的更大的作用。

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