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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Evidence for a role of developmental genes in the origin of obesity and body fat distribution
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Evidence for a role of developmental genes in the origin of obesity and body fat distribution

机译：发育基因在肥胖和体内脂肪分布起源中的作用的证据

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摘要

Obesity, especially central obesity, is a hereditable trait associated with a high risk for development of diabetes and metabolic disorders. Combined gene expression analysis of adipocyte- and preadipocyte-containing fractions from intraabdominal and subcutaneous adipose tissue of mice revealed coordinated depot-specific differences in expression of multiple genes involved in embryonic development and pattern specification. These differences were intrinsic and persisted during in vitro culture and differentiation. Similar depot-specific differences in expression of developmental genes were observed in human subcutaneous versus visceral adipose tissue. Furthermore, in humans, several genes exhibited changes in expression that correlated closely with body mass index and/or waist/hip ratio. Together, these data suggest that genetically programmed developmental differences in adipocytes and their precursors in different regions of the body play an important role in obesity, body fat distribution, and potential functional differences between internal and subcutaneous adipose tissue.
机译：肥胖症，特别是中枢性肥胖症，是一种可遗传的特征，与糖尿病和代谢紊乱发展的高风险有关。小鼠腹腔内和皮下脂肪组织中含脂肪细胞和脂肪细胞的部分的基因表达组合分析表明，参与胚胎发育和模式规范的多个基因的表达具有协调的仓库特异性差异。这些差异是固有的，在体外培养和分化过程中仍然存在。在人皮下组织与内脏脂肪组织中观察到发育基因表达的相似的仓库特异性差异。此外，在人类中，几个基因表现出表达变化，这些变化与体重指数和/或腰围/臀围比率密切相关。总之，这些数据表明，在身体的不同区域中，脂肪细胞及其前体的遗传程序发育差异在肥胖，体内脂肪分布以及内部和皮下脂肪组织之间的潜在功能差异中起着重要作用。

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