• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Ric-8B promotes functional expression of odorant receptors
【24h】

Ric-8B promotes functional expression of odorant receptors

机译：Ric-8B促进气味受体的功能性表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Odorants are detected by a large family of odorant receptors (ORs) expressed in the nose. The information provided by the ORs is transmitted to specific regions of the brain, leading to odorant perception. The determination of the odorant specificities of the different ORs will contribute to the understanding of how odorants are discriminated by the olfactory system. However, to date only a few ORs have been linked to odorants they recognize, because ORs are poorly expressed on the cell surface of heterologous cells. Here we show that Ric-8B, a putative guanine nucleotide exchange factor for G alpha olf, promotes efficient heterologous expression of ORs. Our results also show that Ric-8B enhances accumulation of Gaolf at the cell periphery, indicating that it promotes functional OR expression by improving the efficiency of OR coupling to Gaolf. Expression systems containing Gaolf and Ric-8B should contribute to the functional characterization of ORs.
机译：气味通过鼻子中表达的大量气味受体（OR）来检测。手术室提供的信息被传输到大脑的特定区域，导致嗅觉感知。确定不同OR的气味特异性将有助于理解嗅觉系统如何区分气味。但是，到目前为止，只有少数OR与它们识别的气味相关，因为OR在异源细胞的细胞表面表达较差。在这里，我们显示Ric-8B，一种假定的Gαolf鸟嘌呤核苷酸交换因子，可促进OR的有效异源表达。我们的结果还表明，Ric-8B增强了Gaolf在细胞外围的积累，表明它通过提高OR偶联到Gaolf的效率来促进功能性OR表达。包含Gaolf和Ric-8B的表达系统应有助于OR的功能表征。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号