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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice
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Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice

机译：体育锻炼和代谢补充可减少高胆固醇血症小鼠的自发性动脉粥样硬化斑块破裂并延长生存期

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摘要

Moderate physical exercise (PE) combined with metabolic treatment (MT) (antioxidants and L-arginine) are well known to reduce atherosclerotic lesion formation in hypercholesterolemic mice. However, the long-term beneficial effects on unstable atheroma remain poorly understood. We started early PE training in large groups of 6-week-old hypercholesterolemic mice (by graduated swimming) alone or in combination with nutritional supplementation (1.0% vitamin E added to the chow and 0.05% vitamin C and 6% L-arginine added to the drinking water). Inactive controls did not receive PE. The spontaneous development of atherosclerotic plaque rupture (associated with advanced atherosclerosis) and survival rates were evaluated. Moderate PE elicited an increase in plasma levels of nitric oxide. Early combined treatment with PE and MT in the hypercholesterolemic mice significantly reduced lesions (also detected noninvasively at 10 months) and spontaneous atherosclerotic plaque rupture and prolonged survival more effectively than each intervention alone. Thus, early concerted actions of MT and PE improve the natural history of atherosclerotic lesions and reduce the plaque instability in hypercholesterolemic mice.
机译：众所周知，适度的体育锻炼（PE）与代谢治疗（MT）（抗氧化剂和L-精氨酸）结合可减少高胆固醇血症小鼠的动脉粥样硬化病变的形成。但是，对于不稳定的动脉粥样硬化的长期有益效果仍然知之甚少。我们开始对一大批6周龄的高胆固醇血症小鼠（通过分级游泳）进行单独的体育锻炼，或者与营养补充品（食物中添加1.0％的维生素E，食物中添加0.05％的维生素C和6％的L-精氨酸）一起进行早期体育锻炼饮用水）。不活动的控件未收到PE。评价了动脉粥样硬化斑块破裂的自发发展（与晚期动脉粥样硬化有关）和存活率。中度PE引起血浆一氧化氮水平升高。与高胆固醇血症小鼠相比，PE和MT的早期联合治疗可显着减少病变（在10个月时也以无创方式检测到）和自发性动脉粥样硬化斑块破裂，并且比每次单独干预更有效地延长了生存期。因此，MT和PE的早期协同作用可改善动脉粥样硬化病变的自然病史，并减少高胆固醇血症小鼠的斑块不稳定性。

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