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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Utilizing the information content in two-state trajectories
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Utilizing the information content in two-state trajectories

机译：利用两态轨迹中的信息内容

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摘要

The signal from many single-molecule experiments monitoring molecular processes, such as enzyme turnover by means of fluorescence and opening and closing of ion channel through the flux of ions, consists of a time series of stochastic "on" and "off" (or open and closed) periods, termed a two-state trajectory. This signal reflects the dynamics in the underlying multisubstate on-off kinetic scheme (KS) of the process. The determination of the underlying KS is difficult and sometimes even impossible because of the loss of information in the mapping of the multidimensional KS onto two dimensions. Here we introduce a previously undescribed procedure that efficiently and optimally relates the signal to all equivalent underlying KS. This procedure partitions the space of KS into canonical (unique) forms that can handle any KS and obtains the topology and other details of the canonical form from the data without the need for fitting. Also established are relationships between the data and the topology of the canonical form to the on-off connectivity of a KS. The suggested canonical forms constitute a powerful tool in discriminating between KS. Based on our approach, the upper bound on the information content in two-state trajectories is determined.
机译：来自许多监视分子过程的单分子实验的信号，例如通过荧光作用的酶更新以及通过离子通量打开和关闭离子通道的信号，由随机的“开”和“关”（或打开）时间序列组成。和封闭期间），称为二态轨迹。该信号反映了过程的基础多子状态开关动力学方案（KS）中的动力学。由于在将多维KS映射到二维上时信息丢失，因此确定基础KS是困难的，有时甚至是不可能的。在这里，我们介绍了一个先前未描述的过程，该过程将信号与所有等效的基础KS有效且最佳地关联。此过程将KS的空间划分为可以处理任何KS的规范（唯一）形式，并且无需进行拟合即可从数据中获取拓扑和规范形式的其他详细信息。还建立了数据和规范形式的拓扑到KS的开关连接之间的关系。建议的规范形式是区分KS的有力工具。根据我们的方法，确定了两种状态轨迹中信息内容的上限。

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