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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Liprin-α has LAR-independent functions in R7 photoreceptor axon targeting
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Liprin-α has LAR-independent functions in R7 photoreceptor axon targeting

机译：脂蛋白-α在R7感光轴突靶向中具有LAR独立功能

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摘要

In the Drosophila visual system, the color-sensing photoreceptors R7 and R8 project their axons to two distinct layers in the medulla. Loss of the receptor tyrosine phosphatase LAR from R7 photoreceptors causes their axons to terminate prematurely in the R8 layer. Here we identify a null mutation in the Liprin-α gene based on a similar R7 projection defect. Liprin-α physically interacts with the inactive D2 phosphatase domain of LAR, and this domain is also essential for R7 targeting. However, another LAR-dependent function, egg elongation, requires neither Liprin-α nor the LAR D2 domain. Although human and Caenorhabditis elegans Liprin-α proteins have been reported to control the localization of LAR, we find that LAR localizes to focal adhesions in Drosophila S2R+ cells and to photoreceptor growth cones in vivo independently of Liprin-α. In addition, Liprin-α overexpression or loss of function can affect R7 targeting in the complete absence of LAR. We conclude that Liprin-α does not simply act by regulating LAR localization but also has LAR-independent functions.
机译：在果蝇视觉系统中，颜色感应感光器R7和R8将其轴突投射到延髓的两个不同层。 R7感光细胞受体酪氨酸磷酸酶LAR的丢失导致其轴突过早地终止在R8层中。在这里，我们基于类似的R7投影缺陷识别Liprin-α基因中的无效突变。脂蛋白-α与LAR的非活性D2磷酸酶结构域发生物理相互作用，并且该结构域对于R7靶向也是必不可少的。但是，另一个依赖于LAR的功能（卵伸长）既不需要Liprin-α也不需要LAR D2结构域。尽管已经报道了人类和秀丽隐杆线虫脂蛋白-α蛋白可控制LAR的定位，但我们发现LAR可独立于脂蛋白-α定位于果蝇S2R +细胞中的粘着斑和体内的感光细胞生长锥。此外，在完全不存在LAR的情况下，Liprin-α的过表达或功能丧失会影响R7靶向。我们得出的结论是，Liprin-α不仅通过调节LAR定位起作用，而且还具有LAR独立功能。

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