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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cryptic messages: Is noncoagulant tissue factor reserved for cell signaling?
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Cryptic messages: Is noncoagulant tissue factor reserved for cell signaling?

机译：隐秘消息：非凝血组织因子是否保留用于细胞信号传导？

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摘要

Tissue factor (TF) is the principal initiator of blood clotting in response to vascular injury and in thrombotic disease. TF, an integral membrane protein, is normally excluded from the vascular compartment. Coagulation is initiated when TF is exposed to zymogen coagulation proteases in plasma upon vascular damage. TF first binds factor Ⅶ, supporting both its activation to Ⅶa and activation of factor X (Fig. 1). Factor Xa acts with its cellular cofactor Va to generate thrombin (Ⅱa), which drives both fibrin deposition and platelet aggregation. Thrombin elicits signaling in cells through protease-activated receptors (PARs), a family of G protein-coupled receptors, which are activated proteolytically by unmasking of an N-terminal tethered ligand (Fig. 1). In addition to hemostasis, TF expression and coagulant protease activation have been implicated in inflammation, vascular development, and cancer progression.
机译：组织因子（TF）是响应血管损伤和血栓形成疾病而引起凝血的主要起因。 TF，一种不可或缺的膜蛋白，通常从血管腔中排除。当TF在血管损伤后暴露于血浆中的酶原凝结蛋白酶时，开始凝血。 TF首先结合因子factor，同时支持因子activation的激活和因子X的激活（图1）。 Xa因子与其细胞辅助因子Va共同产生凝血酶（Ⅱa），从而驱动纤维蛋白沉积和血小板聚集。凝血酶通过蛋白酶激活受体（PARs）在细胞中引起信号传导，这是一个G蛋白偶联受体家族，通过揭露N端拴系配体而被蛋白水解激活（图1）。除止血外，TF表达和凝血蛋白酶活化还与炎症，血管发育和癌症进展有关。

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