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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
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A common mechanism underlies stretch activation and receptor activation of TRPC6 channels

机译：常见的机制是TRPC6通道的拉伸激活和受体激活的基础

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摘要

The TRP family of ion channels transduce an extensive range of chemical and physical signals. TRPC6 is a receptor-activated nonselective cation channel expressed widely in vascular smooth muscle and other cell types. We report here that TRPC6 is also a sensor of mechanically and osmotically induced membrane stretch. Pressure-induced activation of TRPC6 was independent of phospholipase C. The stretch responses were blocked by the tarantula peptide, GsMTx-4, known to specifically inhibit mechanosensitive channels by modifying the external lipid-channel boundary. The GsMTx-4 peptide also blocked the activation of TRPC6 channels by either receptor-induced PLC activation or by direct application of diacylglycerol. The effects of the peptide on both stretch- and diacylglycerol-mediated TRPC6 activation indicate that the mechanical and chemical lipid sensing by the channel has a common molecular mechanism that may involve lateral-lipid tension. The mechanosensing properties of TRPC6 channels highly expressed in smooth muscle cells are likely to play a key role in regulating myogenic tone in vascular tissue.
机译：TRP离子通道系列可转换广泛的化学和物理信号。 TRPC6是在血管平滑肌和其他细胞类型中广泛表达的受体激活的非选择性阳离子通道。我们在这里报告说，TRPC6也是机械和渗透诱导的膜拉伸的传感器。压力诱导的TRPC6激活与磷脂酶C无关。伸展反应被狼蛛肽GsMTx-4阻断，该肽已知通过修饰外部脂质通道边界特异性抑制机械敏感通道。 GsMTx-4肽还可以通过受体诱导的PLC激活或直接应用二酰基甘油来阻断TRPC6通道的激活。肽对舒张和二酰基甘油介导的TRPC6活化的影响表明，通道的机械和化学脂质传感具有共同的分子机制，可能涉及侧脂张力。在平滑肌细胞中高度表达的TRPC6通道的机械传感特性可能在调节血管组织的肌原性张力中起关键作用。

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