Electrostatic origin of the genome packing in viruses

Belyi VA; Muthukumar M

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Electrostatic origin of the genome packing in viruses

机译：病毒中基因组堆积的静电起源

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Many ssRNA/ssDNA viruses bind their genome by highly basic semiflexible pepticle arms of capsid proteins. Here, we show that nonspecific electrostatic interactions control both the length of the genome and genome conformations. Analysis of available experimental data shows that the genome length is linear in the net charge on the capsid pepticle arms, irrespective of the actual amino acid sequence, with a proportionality coefficient of 1.61 +/- 0.03. This ratio is conserved across all ssRNA/ssDNA viruses with highly basic pepticle arms, and is different from the one-to-one charge balance expected of specific binding. Genomic nucleoticles are predicted to occupy a radially symmetric spherical shell detached from the viral capsid, in agreement with experimental data.

机译：许多ssRNA / ssDNA病毒通过衣壳蛋白的高度基本的半柔性消化臂结合其基因组。在这里，我们表明非特异性静电相互作用控制基因组的长度和基因组构象。对可用实验数据的分析表明，衣壳消化臂上净电荷中的基因组长度是线性的，与实际氨基酸序列无关，其比例系数为1.61 +/- 0.03。在具有高度碱性的消化臂的所有ssRNA / ssDNA病毒中，该比率都是保守的，并且不同于特异性结合所期望的一对一电荷平衡。与实验数据一致，预计基因组核仁占据与病毒衣壳分离的径向对称球形壳。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2006年第46期|p. 17174-17178|共5页
作者
Belyi VA; Muthukumar M;
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作者单位

Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
polymer assembly; capsid structure; ALFALFA MOSAIC-VIRUS; CONSISTENT-FIELD THEORY; TO-CELL MOVEMENT; CAPSID PROTEIN; SINDBIS VIRUS; COAT PROTEIN; NUCLEOTIDE-SEQUENCE; ICOSAHEDRAL VIRUS; CORE PROTEIN; C-TERMINUS;

机译：聚合物组装;衣壳结构;苜蓿病毒;一致性理论;细胞运动;衣壳蛋白;辛巴比斯病毒;外壳蛋白;核苷酸序列;二十面体病毒;核心蛋白;C-末端;

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6. Electrostatic origin of the genome packing in viruses [O] . Vladimir A. Belyi, M. Muthukumar 2006

机译：病毒中基因组堆积的静电起源
7. Electrostatic origin of the genome packing in viruses [O] . Belyi, Vladimir A., Muthukumar, M. 2006

机译：病毒中基因组堆积的静电起源

Electrostatic origin of the genome packing in viruses

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