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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A three-dimensional model of myxobacterial fruiting-body formation
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A three-dimensional model of myxobacterial fruiting-body formation

机译：粘菌子实体形成的三维模型

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摘要

Myxobacterial cells are social; they swarm by gliding on surfaces as they feed cooperatively. When they sense starvation, tens of thousands of cells change their movement pattern from outward spreading to inward concentration and form aggregates that become fruiting bodies. Cells inside fruiting bodies differentiate into round, nonmotile, environmentally resistant spores. Traditionally, cell aggregation has been considered to imply chemotaxis, a long-range cell interaction that shares many features of chemical reaction-diffusion dynamics. The biological evidence, however, suggests that Myxococcus xanthus aggregation is the consequence of direct cell-contact interactions that are different from chemotaxis. To test whether local interactions suffice to explain the formation of fruiting bodies and the differentiation of spores within them, we have simulated the process. In this article, we present a unified 3D model that reproduces in one continuous simulation all the stages of fruiting-body formation that have been experimentally observed: nonsymmetric initial aggregates (traffic jams), streams, formation of toroidal aggregates, hemispherical 3D mounds, and finally sporulation within the fruiting body.
机译：粘细菌细胞是社交性的。当它们共同进食时，它们通过在表面上滑动而蜂拥而至。当他们感觉到饥饿时，成千上万的细胞将其运动方式从向外扩展变为向内集中，并形成聚集体，形成子实体。子实体内的细胞分化成圆形的，不活动的，耐环境的孢子。传统上，细胞聚集被认为暗示趋化性，这是一种远程细胞相互作用，具有许多化学反应-扩散动力学特征。然而，生物学证据表明，黄色葡萄球菌的聚集是与趋化性不同的直接细胞接触相互作用的结果。为了测试局部相互作用是否足以解释子实体的形成以及其中子实体的分化，我们模拟了该过程。在本文中，我们提供了一个统一的3D模型，该模型在一次连续模拟中重现了实验观察到的子实体形成的所有阶段：非对称初始聚集体（交通拥堵），水流，环形聚集体的形成，半球形3D土丘和最终在子实体中形成孢子。

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