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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Recent history of artificial outcrossing facilitates whole-genome association mapping in elite inbred crop varieties
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Recent history of artificial outcrossing facilitates whole-genome association mapping in elite inbred crop varieties

机译：人工杂交的最新历史促进了优良近交作物品种全基因组关联图谱的建立

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摘要

Genomewide association studies depend on the extent of linkage disequilibrium (LID), the number and distribution of markers, and the underlying structure in populations under study. Outbreeding species generally exhibit limited LD, and consequently, a very large number of markers are required for effective whole-genome association genetic scans. In contrast, several of the world's major food crops are self-fertilizing inbreeding species with narrow genetic bases and theoretically extensive LD. Together these are predicted to result in a combination of low resolution and a high frequency of spurious associations in LID-based studies. However, inbred elite plant varieties represent a unique human-induced pseudooutbreeding population that has been subjected to strong selection for advantageous alleles. By assaying 1,524 genomewide SNIPS we demonstrate that, after accounting for population substructure, the level of LID exhibited in elite northwest European barley, a typical inbred cereal crop, can be effectively exploited to map traits,by using whole-genome association scans with several hundred to,thousands of biallelic SNPs.
机译：全基因组关联研究取决于连锁不平衡（LID）的程度，标记的数量和分布以及所研究人群的基础结构。远交种通常表现出有限的LD，因此，有效的全基因组关联遗传扫描需要大量的标记。相比之下，世界上几种主要的粮食作物是遗传基础狭窄，理论上讲LD较差的自交近交种。在基于LID的研究中，预计这些因素将共同导致低分辨率和高频率的虚假关联。然而，近交优良植物品种代表了独特的人类诱导的假近交种群，已经对有利的等位基因进行了强大的选择。通过分析1,524个全基因组SNIPS，我们证明，在考虑了人口子结构之后，通过使用数百个全基因组关联扫描，可以有效地利用西北北欧大麦（一种典型的近交谷物）中表现出的LID水平来绘制性状。到数千个双等位基因SNP。

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