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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Unique characteristics of Xanthomonas oryzae pv. oryzae AvrXa21 and implications for plant innate immunity
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Unique characteristics of Xanthomonas oryzae pv. oryzae AvrXa21 and implications for plant innate immunity

机译:Xanthomonas oryzae pv的独特特征。米AvrXa21及其对植物固有免疫的影响

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This article provides a brief overview of some of the major concepts and molecular features of plant and animal innate immune systems. The rice pathogen recognition receptor, XA21, confers resistance to Xanthomonas oryzae pv. oryzae strains producing the AvrXa21 elicitor. Xa21 codes for a receptor-like kinase consisting of an extracellular leucine-rich repeat domain, a transmembrane domain, and a cytoplasmic kinase domain. We show that AvrXa21 activity requires the presence of rax (required for AvrXa21) A, raxB, and raxC genes that encode components of a type one secretion system. In contrast, an hrpC(-) strain deficient in type three secretion maintains AvrXa21 activity. Xanthomonas campestris pv. campestris can express AvrXa21 activity if raxST, encoding a putative sulfotransferase, and raxA are provided in trans. Expression of rax genes depends on population density and other functioning rax genes. This and other data suggest that the AvrXa21 pathogen-associated molecule is involved in quorum sensing. Together these data suggest that AvrXa21 represents a previously uncharacterized class of Gram-negative bacterial signaling molecules. These results from our studies of the XA21/AvrXa21 interaction call for some modifications in the way we think about innate immunity strategies.
机译:本文简要概述了植物和动物先天免疫系统的一些主要概念和分子特征。水稻病原体识别受体XA21赋予了对米黄单胞菌(Xanthomonas oryzae pv)的抗性。产生AvrXa21激发子的米曲菌株。 Xa21编码由胞外富亮氨酸重复结构域,跨膜结构域和胞质激酶结构域组成的受体样激酶。我们显示,AvrXa21活动需要rax(AvrXa21必需)A,raxB和raxC基因的存在,它们编码一种类型的分泌系统的成分。相反,缺乏三型分泌物的hrpC(-)菌株维持AvrXa21活性。 Xanthomonas campestris PV。如果反式提供编码推定的磺基转移酶的raxST和raxA,则campestris可以表达AvrXa21活性。 rax基因的表达取决于种群密度和其他功能性rax基因。该数据和其他数据表明,AvrXa21病原体相关分子参与群体感应。这些数据共同表明,AvrXa21代表了先前未鉴定出的革兰氏阴性细菌信号分子。我们对XA21 / AvrXa21相互作用的研究得出的这些结果要求我们对先天免疫策略的思考方式进行一些修改。

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