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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Dendritic spines linearize the summation of excitatory potentials
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Dendritic spines linearize the summation of excitatory potentials

机译：树突棘使兴奋电位的总和线性化

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In mammalian cortex, most excitatory inputs occur on dendritic spines, avoiding dendritic shafts. Although spines biochemically isolate inputs, nonspiny neurons can also implement biochemical compartmentalization; so, it is possible that spines have an additional function. We have recently shown that the spine neck can filter membrane potentials going into and out of the spine. To investigate the potential function of this electrical filtering, we used two-photon uncaging of glutamate and compared the integration of electrical signals in spines vs. dendritic shafts from basal dendrites of mouse layer 5 pyramidal neurons. Uncaging potentials onto spines summed linearly, whereas potentials on dendritic shafts reduced each other's effect. Linear integration of spines was maintained regardless of the amplitude of the response, distance between spines (as close as < 2 mu m), distance of the spines to the soma, dendritic diameter, or spine neck length. our findings indicate that spines serve as electrical isolators to prevent input interaction, and thus generate a linear arithmetic of excitatory inputs. Linear integration could be an essential feature of cortical and other spine-laden circuits.
机译：在哺乳动物皮质中，大多数兴奋性输入发生在树突棘上，避免了树突干。尽管棘生化分离了输入，但非多刺神经元也可以实现生化分隔。因此，刺可能具有附加功能。我们最近显示，脊柱颈部可以过滤进出脊柱的膜电位。为了研究这种电过滤的潜在功能，我们使用了谷氨酸的双光子解笼，并比较了来自小鼠第5层锥体神经元基底树突的棘轴与树突轴的电信号积分。棘上未笼化的电势线性地求和，而树突轴上的电势降低了彼此的影响。无论响应幅度，棘突之间的距离（最短<2μm），棘突与躯干的距离，树突直径或脊柱颈长如何，都可以保持棘突的线性整合。我们的发现表明，棘刺可作为电气隔离器来防止输入相互作用，从而生成激励性输入的线性算法。线性积分可能是皮质回路和其他充满脊柱的回路的基本特征。

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