...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.
【24h】

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.

机译：微管结合药物通过稳定微管并逆转tauopathy模型中的快速轴突运输缺陷来抵消tau隔离。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We tested the hypothesis that microtubule (MT)-binding drugs could be therapeutically beneficial in tauopathies by functionally substituting for the MT-binding protein tau, which is sequestered into inclusions of human tauopathies and transgenic mouse models thereof. Transgenic mice were treated for 12 weeks with weekly i.p. injections of 10 or 25 mg/m(2) paclitaxel (Paxceed). Both doses restored fast axonal transport in spinal axons, wherein MT numbers and stable (detyrosinated) tubulins were increased, compared with sham treatment, and only Paxceed ameliorated motor impairments in tau transgenic mice. Thus, MT-stabilizing drugs could have therapeutic potential for treating neurodegenerative tauopathies by offsetting losses of tau function that result from the sequestration of this MT-stabilizing protein into filamentous inclusions.
机译：我们测试了这样的假说，即微管（MT）结合药物可以通过功能上替代MT结合蛋白tau来治疗tauopathy的疾病，该蛋白被螯合到人类tauopathies及其转基因小鼠模型的内含物中。用每周一次腹膜内注射治疗转基因小鼠12周。注射10或25 mg / m（2）紫杉醇（Paxceed）。与假手术相比，两种剂量均能恢复脊髓轴突中的轴突快速运输，其中MT数量和稳定的（去酪氨酸化的）微管蛋白均增加，而tau转基因小鼠中Paxceed只能改善运动障碍。因此，稳定MT的药物通过抵消由于将MT稳定蛋白螯合成丝状内含物而导致的tau功能丧失，可能具有治疗神经退行性病变的治疗潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号