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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Stochastic amplification and signaling in enzymatic futile cycles through noise-induced bistability with oscillations
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Stochastic amplification and signaling in enzymatic futile cycles through noise-induced bistability with oscillations

机译：通过噪声诱导的双稳态和振荡在酶的无用循环中进行随机扩增和信号传递

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摘要

Stochastic effects in biomolecular systems have now been recognized as a major physiologically and evolutionarily important factor in the development and function of many living organisms. Nevertheless, they are often thought of as providing only moderate refinements to the behaviors otherwise predicted by the classical deterministic system description. In this work we show by using both analytical and numerical investigation that at least in one ubiquitous class of (bio)chemical-reaction mechanisms, enzymatic futile cycles, the external noise may induce a bistable oscillatory (dynamic switching) behavior that is both quantitatively and qualitatively different from what is predicted or possible deterministically. We further demonstrate that the noise required to produce these distinct properties can itself be caused by a set of auxiliary chemical reactions, making it feasible for biological systems of sufficient complexity to generate such behavior internally. This new stochastic dynamics then serves to confer additional functional modalities on the enzymatic futile cycle mechanism that include stochastic amplification and signaling, the characteristics of which could be controlled by both the type and parameters of the driving noise. Hence, such noise-induced phenomena may, among other roles, potentially offer a novel type of control mechanism in pathways that contain these cycles and the like units. In particular, observations of endogenous or externally driven noise-induced dynamics in regulatory networks may thus provide additional insight into their topology, structure, and kinetics.
机译：现在已经认识到生物分子系统中的随机作用是许多生物的发育和功能的主要生理和进化重要因素。但是，通常认为它们仅对经典确定性系统描述所预测的行为提供适度的改进。在这项工作中，我们通过分析和数值研究表明，至少在一种普遍存在的（生物）化学反应机制中，酶促无功循环中，外部噪声可能会诱发双稳态振荡（动态切换）行为，这种行为在数量上和在质量上与预测的或确定性的不同。我们进一步证明，产生这些不同性质所需的噪声本身可以由一组辅助化学反应引起，这使得具有足够复杂性的生物系统在内部产生这种行为成为可能。然后，这种新的随机动力学用于在酶的无用循环机制上赋予其他功能形式，包括随机放大和信号传递，其特性可以由行驶噪声的类型和参数来控制。因此，除其他作用外，这种噪声引起的现象还可能在包含这些循环等单元的路径中提供一种新型的控制机制。特别是，对调节网络中内源性或外部驱动的噪声引起的动力学的观察可能因此提供了对其拓扑，结构和动力学的更多了解。

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