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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Low levels of linkage disequilibrium in wild barley (Hordeum vulgare ssp. spontaneuni) despite high rates of self-fertilization
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Low levels of linkage disequilibrium in wild barley (Hordeum vulgare ssp. spontaneuni) despite high rates of self-fertilization

机译：尽管自体受精率很高，但野生大麦（大麦属植物spontaneuni）的连锁不平衡水平较低

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摘要

High levels of inbreeding cause populations to become composed of homozygous, inbred lines. High levels of homozygosity limit the effectiveness of recombination, and therefore, retard the rate of decay of linkage (gametic phase) disequilibrium (LD) among mutations. Inbreeding and recombination interact to shape the expected pattern of LD. The actual extent of nucleotide sequence level LD within inbreeding species has only been studied in Ara-bidopsis, a weedy species whose global range has recently expanded. In the present study, we examine the levels of LD within and between 18 nuclear genes in 25 accessions from across the geographic range of wild barley, a species with a selfing rate of ≈98℅. In addition to examination of intralocus LD, we employ a resampling method to determine whether interlocus LD exceeds expectations. We demonstrate that, for the majority of wild barley loci, intralocus LD decays rapidly, i.e., at a rate similar to that observed in the outcrossing species, Zea mays (maize). Excess interlocus LD is observed at 15℅ of two-locus combinations; almost all interlocus LD involves loci with significant geographic structuring of mutational variation.
机译：高水平的近交会导致种群由纯合的近交系组成。高水平的纯合性限制了重组的有效性，因此，阻碍了突变之间连锁（配子期）不平衡（LD）的衰减速率。近交和重组相互作用以形成预期的LD模式。近交物种中核苷酸序列水平LD的实际程度仅在Ara-bidopsis中得到了研究，Ara-bidopsis是一种杂草，其全球范围最近有所扩大。在本研究中，我们研究了野生大麦（自交率约为98℅的物种）的25个种质中18个核基因中和18个核基因之间的LD水平。除了检查轨迹内LD外，我们还采用了一种重采样方法来确定轨迹间LD是否超出预期。我们证明，对于大多数野生大麦基因座，位点内LD迅速衰减，即以类似于异交物种玉米（玉米）中观察到的速率衰减。在两个位点组合的15度处观察到过量的位点间LD。几乎所有的中间位点LD都与突变变异的重要地理结构有关。

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