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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A circuit for navigation in Caenorhabditis elegans
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A circuit for navigation in Caenorhabditis elegans

机译：秀丽隐杆线虫的导航电路

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摘要

Caenorhabditis elegans explores its environment by interrupting its forward movement with occasional turns and reversals. Turns and reversals occur at stable frequencies but irregular intervals, producing probabilistic exploratory behaviors. Here we dissect the roles of individual sensory neurons, interneurons, and motor neurons in exploratory behaviors under different conditions. After animals are removed from bacterial food, they initiate a local search behavior consisting of reversals and deep omega-shaped turns triggered by AWC olfactory neurons, ASK gustatory neurons, and AIB interneurons. Over the following 30 min, the animals disperse as reversals and omega turns are suppressed by ASI gustatory neurons and AIY interneurons. Interneurons and motor neurons downstream of AIB and AIY encode specific aspects of reversal and turn frequency, amplitude, and directionality. SMD motor neurons help encode the steep amplitude of omega turns, RIV motor neurons specify the ventral bias of turns that follow a reversal, and SMB motor neurons set the amplitude of sinusoidal movement. Many of these sensory neurons, interneurons, and motor neurons are also implicated in chemotaxis and thermotaxis. Thus, this circuit may represent a common substrate for multiple navigation behaviors.
机译：秀丽隐杆线虫通过偶尔的转弯和反转来中断其向前运动来探索其环境。转弯和反转以稳定的频率但不规则的间隔发生，从而产生概率的探索行为。在这里，我们剖析了在不同条件下的探索行为中单个感觉神经元，中间神经元和运动神经元的作用。将动物从细菌食物中移出后，它们会发起由AWC嗅觉神经元，ASK味觉神经元和AIB中间神经元触发的逆转和深Ω形转弯组成的局部搜索行为。在接下来的30分钟内，动物以逆转的方式散开，ω转向被ASI味觉神经元和AIY中神经元抑制。 AIB和AIY下游的中间神经元和运动神经元编码反转和转折频率，幅度和方向性的特定方面。 SMD运动神经元帮助编码欧米茄转弯的陡峭幅度，RIV运动神经元指定反转后转弯的腹侧偏斜，而SMB运动神经元设置正弦运动的幅度。这些感觉神经元，中间神经元和运动神经元中的许多也与趋化性和趋热性有关。因此，该电路可以代表用于多种导航行为的通用基板。

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