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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The CD4 molecule on CD8~+ T lymphocytes directly enhances the immune response to viral and cellular antigens
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The CD4 molecule on CD8~+ T lymphocytes directly enhances the immune response to viral and cellular antigens

机译：CD8〜+ T淋巴细胞上的CD4分子直接增强了对病毒和细胞抗原的免疫反应

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CD8~+ T lymphocytes play a major role in cellular-mediated immune responses to foreign antigen. We have previously demonstrated that costimulation of purified human CD8~+ T cells induces de novo expression of the CD4 molecule and that ligation of CD4 on this cell type modulates CD8~+ T cell activity in vitro. Herein, we investigate how the CD4 molecule expressed on murine CD8~+ T cells contributes to CD8~+ cell responses in vivo by employing adoptive transfer of CD8 cells from CD4 knockout mice into severe combined immu-nodeficient (SCID) recipients. Transfer of these cells into syngeneic SCID mice resulted in a decreased immune response to infection by lymphocytic choriomeningitis virus. These decreased responses occurred even in the presence of CD4~+ T cells, indicating that this was truly a CD8-cell defect. Similarly, transfer of CD8~+ T cells incapable of expressing CD4 into allogeneic SCID mice resulted in a decreased response to alloantigens compared with that of normal CD8~+ T cells. Therefore, CD4 expression on CD8 T lymphocytes modulates cytotoxic T lymphocyte function and is critical in vivo for optimal cell-mediated immunity to viral and alloantigens.
机译：CD8〜+ T淋巴细胞在细胞介导的针对外源抗原的免疫反应中起主要作用。先前我们已经证明，纯化的人CD8〜+ T细胞的共刺激诱导CD4分子的从头表达，并且CD4在这种细胞类型上的连接会在体外调节CD8〜+ T细胞的活性。本文中，我们研究了通过将CD8细胞从CD4基因敲除小鼠转移到严重的联合免疫缺陷（SCID）受体中，鼠CD8〜+ T细胞上表达的CD4分子如何在体内促进CD8〜+细胞反应。这些细胞转移到同基因SCID小鼠中导致对淋巴细胞性脉络膜脑膜炎病毒感染的免疫反应降低。这些降低的反应甚至在存在CD4 + T细胞的情况下也发生，表明这确实是CD8细胞缺陷。类似地，与正常CD8 + T细胞相比，将不能表达CD4的CD8 + T细胞转移到同种SCID小鼠中，导致对同种抗原的应答降低。因此，CD8 T淋巴细胞上的CD4表达调节细胞毒性T淋巴细胞的功能，并且在体内对于最佳的细胞介导的对病毒和同种抗原的免疫力至关重要。

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