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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Architectural and synaptic mechanisms underlying coherent spontaneous activity in V1
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Architectural and synaptic mechanisms underlying coherent spontaneous activity in V1

机译：V1相干自发活动的基础结构和突触机制

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摘要

To investigate the existence and the characteristics of possible cortical operating points of the primary visual cortex, as manifested by the coherent spontaneous ongoing activity revealed by real-time optical imaging based on voltage-sensitive dyes, we studied numerically a very large-scale (≈5 x 10~5) conductance-based, integrate-and-fire neuronal network model of an ≈ 16-mm~2 patch of 64 orientation hypercolumns, which incorporates both isotropic local couplings and lateral orientation-specific long-range connections with a slow NMDA component. A dynamic scenario of an intermittent desuppressed state (IDS) is identified in the computational model, which is a dynamic state of (ⅰ) high conductance, (ⅱ) strong inhibition, and (ⅲ) large fluctuations that arise from intermittent spiking events that are strongly correlated in time as well as in orientation domains, with the correlation time of the fluctuations controlled by the NMDA decay time scale. Our simulation results demonstrate that the IDS state captures numerically many aspects of experimental observation related to spontaneous ongoing activity, and the specific network mechanism of the IDS may suggest cortical mechanisms and the cortical operating point underlying observed spontaneous activity.
机译：为了研究主要视觉皮层的可能皮质工作点的存在和特征，以基于电压敏感染料的实时光学成像揭示的连贯的自发进行性活动为证据，我们在数值上进行了大规模研究（ 5 x 10〜5）基于电导的，积分和发射的神经元网络模型，由64个定向超柱组成的≈16-mm〜2贴片，其中包括各向同性的局部耦合和侧向特定的长距离连接，且速度较慢NMDA组件。在计算模型中确定了间歇性抑制状态（IDS）的动态场景，该状态是（ⅰ）高电导，（ⅱ）强抑制和（ⅲ）间歇性尖峰事件引起的大波动，在时间和方向域上都具有很强的相关性，与由NMDA衰减时间尺度控制的波动的相关时间有关。我们的模拟结果表明，IDS状态从数值上捕获了与自发进行性活动有关的实验观察的许多方面，并且IDS的特定网络机制可能暗示了观察到的自发活动的皮质机制和皮质工作点。

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