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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens
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Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens

机译：D1和伏隔核中NMDA受体对食性巴甫洛夫记忆的时限调节

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摘要

Recent research has implicated the nucleus accumbens (NAc) in consolidating recently acquired goal-directed appetitive memories, including spatial learning and other instrumental processes. However, an important but unresolved issue is whether this forebrain structure also contributes to the consolidation of fundamental forms of appetitive learning acquired by Pavlovian associative processes. In addition, although dopaminergic and gluta-matergic influences in the NAc have been implicated in instrumental learning, it is unclear whether similar mechanisms operate during Pavlovian conditioning. To evaluate these issues, the effects of posttraining intra-NAc infusions of D1, D2, and NMDA receptor antagonists, as well as D-amphetamine, were determined on Pavlovian autoshaping in rats, which assesses learning by discriminated approach behavior to a visual conditioned stimulus predictive of food reward. Intracerebral infusions were given either immediately after each conditioning session to disrupt early memory consolidation or after a delay of 24 h. Findings indicate that immediate, but not delayed, infusions of both D1 (SCH 23390) and NMDA (AP-5) receptor antagonists significantly impair learning on this task. By contrast, amphetamine and the D2 receptor antagonist sulpiride were without significant effect. These findings provide the most direct demonstration to date that D1 and NMDA receptors in the NAc contribute to, and are necessary for, the early consolidation of appetitive Pavlovian learning.
机译：最近的研究表明伏隔核（NAc）整合了最近获得的目标导向的记忆，包括空间学习和其他工具过程。但是，一个重要但尚未解决的问题是，这种前脑结构是否也有助于巩固巴甫洛夫式联想过程获得的基本形式的学习性学习。此外，尽管NAc中的多巴胺能和谷氨酸能影响与工具学习有关，但尚不清楚在巴甫洛夫式调节过程中类似的机制是否起作用。为了评估这些问题，确定了训练后的NAc内D1，D2和NMDA受体拮抗剂以及D-苯异丙胺的输注对大鼠巴甫洛夫自动定形的影响，后者通过对有条件的视觉刺激的区分进场行为来评估学习预测食物奖励。在每次调理疗程后立即进行脑内输注，以中断早期记忆巩固，或延迟24小时后给予。研究结果表明，立即但不延迟输注D1（SCH 23390）和NMDA（AP-5）受体拮抗剂都严重损害了对该任务的学习。相比之下，苯丙胺和D2受体拮抗剂舒必利没有明显作用。这些发现提供了迄今为止最直接的证明，NAc中的D1和NMDA受体有助于及早吸收开胃的巴甫洛夫式学习。

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