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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response
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Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response

机译：人体赖氨酰-tRNA合成酶被分泌引发促炎反应

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摘要

Although aminoacyl-tRNA synthetases (ARSs) are essential for protein synthesis, they also function as regulators and signaling molecules in diverse biological processes. Here, we screened 11 different human ARSs to identify the enzyme that is secreted as a signaling molecule. Among them, we found that lysyl-tRNA synthetase (KRS) was secreted from intact human cells, and its secretion was induced by TNF-α. The secreted KRS bound to macrophages and peripheral blood mononuclear cells to enhance the TNF-α production and their migration. The mitogen-activated protein kinases, extracellular signal-regulated kinase and p38 mitogen-activated protein kinase, and Gαi were determined to be involved in the signal transduction triggered by KRS. All of these activities demonstrate that human KRS may work as a previously uncharacterized signaling molecule, inducing immune response through the activation of monocyte macrophages.
机译：尽管氨酰基tRNA合成酶（ARS）对于蛋白质合成至关重要，但它们在多种生物过程中也起调节剂和信号分子的作用。在这里，我们筛选了11种不同的人类ARS，以鉴定作为信号分子分泌的酶。其中，我们发现完整人类细胞分泌赖氨酰-tRNA合成酶（KRS），其分泌是由TNF-α诱导的。分泌的KRS与巨噬细胞和外周血单核细胞结合，以增强TNF-α的产生及其迁移。已确定有丝分裂原激活的蛋白激酶，细胞外信号调节激酶和p38丝裂原激活的蛋白激酶以及Gαi参与了KRS触发的信号转导。所有这些活动证明，人类KRS可能作为以前未表征的信号分子起作用，通过单核巨噬细胞的激活诱导免疫应答。

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