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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Genomic and proteomic comparisons between bacterial and archaeal genomes and related comparisons with the yeast and fly genomes
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Genomic and proteomic comparisons between bacterial and archaeal genomes and related comparisons with the yeast and fly genomes

机译：细菌和古细菌基因组之间的基因组和蛋白质组比较，以及酵母和果蝇基因组的相关比较

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摘要

Bacterial, archaeal, yeast, and fly genomes are compared with respect to predicted highly expressed (PHX) genes and several genomic properties. There is a striking difference in the status of PHX ribosomal protein (RP) genes where the archaeal genome generally encodes more RP genes and fewer PHX RPs compared with bacterial genomes. The increase in RPs in archaea and eu-karyotes compared with that in bacteria may reflect a more complex set of interactions in archaea and eukaryotes in regulating translation, e.g., differences in structure requiring scaffolding of longer rRNA molecules, expanded interactions with the chaperone machinery, and, in eukaryotic interactions with endoplasmic retic-ulum components. The yeast genome is similar to fast-growing bacteria in PHX genes but also features several cytoskeletal genes, including actin and tropomyosin, and several signal transduction regulatory proteins from the 14.3.3 family. The most PHX genes of Drosophila encode cytoskeletal and exoskeletal proteins. We found that the preference of a microorganism for an anaerobic metabolism correlates with the number of PHX enzymes of the glycolysis pathway that well exceeds the number of PHX enzymes acting in the tricarboxylic acid cycle. Conversely, if the number of PHX enzymes of the tricarboxylic acid cycle well exceeds the PHX enzymes of glycolysis, an aerobic metabolism is preferred. Where the numbers are approximately commensurate, a facultative growth behavior prevails.
机译：将细菌，古细菌，酵母和果蝇的基因组与预测的高表达（PHX）基因和几种基因组特性进行了比较。与细菌基因组相比，PHX核糖体蛋白（RP）基因的状态存在显着差异，其中古细菌基因组通常编码更多的RP基因和更少的PHX RP。与细菌相比，古细菌和真核生物中RP的增加可能反映了古细菌和真核生物在调节翻译中更为复杂的相互作用，例如，结构上的差异需要更长的rRNA分子的支架，与伴侣分子机制的扩展相互作用，以及与内质网-尿液成分的真核相互作用。酵母基因组与PHX基因中快速生长的细菌相似，但也具有几个细胞骨架基因，包括肌动蛋白和原肌球蛋白，以及来自14.3.3家族的几个信号转导调节蛋白。果蝇的大多数PHX基因编码细胞骨架和骨骼外蛋白。我们发现，微生物对厌氧代谢的偏好与糖酵解途径的PHX酶的数量相关，该数量大大超过了在三羧酸循环中起作用的PHX酶的数量。相反，如果三羧酸循环的PHX酶的数量大大超过糖酵解的PHX酶，则优选有氧代谢。当数字大致相当时，兼性的生长行为占主导。

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