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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7
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Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7

机译：GDF7将顶板中的晚期神经c细胞迁移至感觉上的命运

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摘要

Lineage-tracing experiments have shown that some premigratory neural crest cells generate both sensory (S) and autonomic (A) derivatives, whereas others generate only S derivatives. Whether this lineage heterogeneity reflects random variation in a homogeneous population or an early sensory specification of some premi-gratory crest cells has not been clear. Using Cre recombinase-based fate mapping, we show that GDF7, which is exclusively expressed in the roof plate, marks neural crest cells with a 10-fold higher bias to the sensory lineage than those marked (at the same stage of development) by an inducible Wnt1-Cre, which is expressed more broadly in the dorsal neural tube. In vitro, GDF7 has potent sensory neuron-inducing activity. These data suggest that some premigra-tory crest cells are deterministically restricted to the S lineage and implicate GDF7 itself in this restriction process.
机译：谱系追踪实验表明，一些迁徙前神经rest细胞同时产生感觉（S）和自主（A）衍生物，而其他仅产生S衍生物。目前尚不清楚这种谱系异质性是否反映了同质种群中的随机变化或某些早孕cells细胞的早期感觉指标。使用基于Cre重组酶的命运定位图，我们显示了仅在顶板上表达的GDF7标记的神经rest细胞对感觉谱系的偏向比在（发育的同一阶段）标记的神经those细胞高10倍。诱导型Wnt1-Cre，在背神经管中更广泛地表达。在体外，GDF7具有有效的感觉神经元诱导活性。这些数据表明，某些早c细胞被确定性地限制于S谱系，并在该限制过程中牵涉到GDF7本身。

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