...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Virulence and competitive ability in genetically diverse malaria infections
【24h】

Virulence and competitive ability in genetically diverse malaria infections

机译：基因多样性疟疾感染中的毒力和竞争能力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Explaining parasite virulence is a great challenge for evolutionary biology. Intuitively, parasites that depend on their hosts for their survival should be benign to their hosts, yet many parasites cause harm. One explanation for this is that within-host competition favors virulence, with more virulent strains having a competitive advantage in genetically diverse infections. This idea, which is well supported in theory, remains untested empirically. Here we provide evidence that within-host competition does indeed select for high parasite virulence. We examine the rodent malaria Plasmo-dium chabaudi in laboratory mice, a parasite-host system in which virulence can be easily monitored and competing strains quantified by using strain-specific real-time PCR. As predicted, we found a strong relationship between parasite virulence and competitive ability, so that more virulent strains have a competitive advantage in mixed-strain infections. In transmission experiments, we found that the strain composition of the parasite populations in mosquitoes was directly correlated with the composition of the blood-stage parasite population. Thus, the outcome of within-host competition determined relative transmission success. Our results imply that within-host competition is a major factor driving the evolution of virulence and can explain why many parasites harm their hosts.
机译：解释寄生虫毒力是进化生物学面临的巨大挑战。直觉上，依赖宿主生存的寄生虫对宿主应是良性的，但是许多寄生虫会造成伤害。对此的一种解释是，宿主内部竞争有利于毒力，更具毒性的毒株在遗传多样的感染中具有竞争优势。这个想法在理论上得到了很好的支持，但在经验上尚未得到检验。在这里，我们提供了证据，证明宿主内竞争确实选择了高寄生虫毒力。我们在实验室小鼠中检查了啮齿动物疟疾疟原虫chabaudi，这是一种寄生虫-宿主系统，在该系统中可以轻松监测毒力并使用菌株特异性实时PCR定量竞争菌株。如预测的那样，我们发现寄生虫毒力与竞争能力之间存在很强的关系，因此更具毒性的菌株在混合菌株感染中具有竞争优势。在传播实验中，我们发现蚊子中寄生虫种群的菌株组成与血液阶段寄生虫种群的组成直接相关。因此，主办方内部竞争的结果决定了相对传播的成功。我们的结果表明，宿主内部竞争是驱动毒力进化的主要因素，并且可以解释为什么许多寄生虫会伤害其宿主。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号