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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Stress release drives symmetry breaking for actin-based movement
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Stress release drives symmetry breaking for actin-based movement

机译:应力释放驱动基于肌动蛋白的运动对称性破坏

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摘要

By using a simple assay composed of purified proteins, we studied the spontaneous polarization of actin networks polymerizing on spherical beads, which subsequently undergo movement. We show evidence that this symmetry breaking is based on the release of elastic energy, analogous to the fracture of polymer gels. The dynamics of this process and the thickness at which it occurs depend on the growth rate and mechanical properties of the actin gel. We explain our experimental results with a model based on elasticity theory and fracture mechanics.
机译:通过使用由纯化的蛋白质组成的简单测定方法,我们研究了在球形珠子上聚合的肌动蛋白网络的自发极化,随后球蛋白发生运动。我们显示出这种对称破坏的证据是基于弹性能的释放,类似于聚合物凝胶的断裂。该过程的动力学及其发生的厚度取决于肌动蛋白凝胶的生长速率和机械性能。我们使用基于弹性理论和断裂力学的模型来解释我们的实验结果。

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