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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Epidermal growth factor prevents prepartum luteolysis in the rat
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Epidermal growth factor prevents prepartum luteolysis in the rat

机译：表皮生长因子防止大鼠产前黄体溶解

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摘要

We have previously reported that intrauterine (i/u) administration of epidermal growth factor (EGF 500 ng) on day (d) 21 of pregnancy delayed 19.0 ± 0.6 h the onset of labor. Progesterone (P) is secreted by ovarian corpora lutea (CL) throughout gestation in the rat. Prepartum CL regression due to increased uterine cyclooxygenase I and prostaglandin F_(2α) results in P withdrawal followed by labor. The aims of the present work were (ⅰ) to study whether EGF delayed-onset of labor was mediated by a mechanism that prevented CL regression; (ⅱ) to determine amniotic fluid (AF) EGF in pregnant rats. Rats on d21 of pregnancy received i/u EGF (500 ng) and were killed 0, 4, 8,12, 24, and 48 h later. Control AF from rats on d13 and 18-22 of pregnancy was obtained. EGF decreased uterine prostaglandin F_(2α) synthesis 8 h after treatment. Twelve hours after EGF injection, P reached its highest serum level and uterine cyclooxygenase I expression was undetectable, CL from rats killed 8 and 12 h after EGF were similar to those from rats on d13 of pregnancy, when serum P is maximum. EGF in AF increased throughout gestation, reached a maximum on d21, and decreased before the onset of labor. We suggest that the effect of EGF on the onset of labor was mediated by an early effect on the uterus that prevented prepartum CL regression.
机译：我们以前曾报道过，在妊娠第21天子宫内（i / u）施用表皮生长因子（EGF 500 ng）会延迟分娩19.0±0.6 h。整个妊娠期间，卵巢黄体（CL）都会分泌孕酮（P）。由于子宫环氧合酶I和前列腺素F_（2α）增加而导致的产前CL消退导致P撤退，然后分娩。本研究的目的是（ⅰ）研究EGF延迟分娩是否是由防止CL消退的机制介导的； （ⅱ）测定妊娠大鼠的羊水（AF）EGF。妊娠第21天的大鼠接受i / u EGF（500 ng），并在0、4、8、12、24和48小时后处死。在怀孕的第13天和第18-22天从大鼠获得对照AF。 EGF在治疗后8小时降低了子宫前列腺素F_（2α）的合成。 EGF注射后12小时，P达到最高血清水平，而子宫环氧合酶I表达未检出，EGF分别在8和12 h处死的大鼠的CL与妊娠d13时的大鼠相似（当时血清P最大）。 AF的EGF在整个妊娠过程中均增加，在第21天达到最大值，并在分娩前降低。我们建议，EGF对分娩发作的影响是由对子宫的早期影响所介导的，阻止了产前CL的消退。

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