The telomerase reverse transcriptase regulates chromatin state and DNA damage responses

Kenkichi Masutomi; Richard Possemato; Judy M. Y. Wong; Jennifer L. Currier; Zuzana Tothova; Judith B. Manola; Shridar Ganesan; Peter M. Lansdorp; Kathleen Collins; William C. Hahn

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses

机译：端粒酶逆转录酶调节染色质状态和DNA损伤反应

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Constitutive expression of telomerase prevents senescence and crisis by maintaining telomere homeostasis. However, recent evidence suggests that telomerase is dynamically regulated in normal cells and also contributes to transformation independently of net telomere elongation. Here, we show that suppression of the telomerase catalytic subunit [human telomerase reverse transcriptase (hTERT)] expression abrogates the cellular response to DNA double strand breaks. Loss of hTERT does not alter short-term telomere integrity but instead affects the overall configuration of chromatin. Cells lacking hTERT exhibit increased radiosensitivity, diminished capacity for DNA repair, and fragmented chromosomes, demonstrating that loss of hTERT impairs the DNA damage response.

机译：端粒酶的组成型表达通过维持端粒稳态来防止衰老和危机。然而，最近的证据表明，端粒酶在正常细胞中是动态调节的，并且也独立于净端粒伸长而有助于转化。在这里，我们表明抑制端粒酶催化亚基[人类端粒酶逆转录酶（hTERT）]表达消除了细胞对DNA双链断裂的反应。 hTERT的丧失不会改变短期的端粒完整性，而是会影响染色质的整体结构。缺乏hTERT的细胞表现出更高的放射敏感性，DNA修复能力下降和染色体断裂，表明hTERT的丧失会损害DNA损伤反应。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2005年第23期|p.8222-8227|共6页
作者
Kenkichi Masutomi; Richard Possemato; Judy M. Y. Wong; Jennifer L. Currier; Zuzana Tothova; Judith B. Manola; Shridar Ganesan; Peter M. Lansdorp; Kathleen Collins; William C. Hahn;
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作者单位

Departments of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
human telomerase reverse transcriptase; histone modification; genomic integrity;

机译：人端粒酶逆转录酶;组蛋白修饰;基因组完整性;

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1. Telomerase reverse transcriptase (TERT) ‐ enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA DNA damage responses in glioblastoma [J] . Ahmad Fahim, Patrick Shruti, Sheikh Touseef, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2017,第6期

机译：端粒酶逆转录酶（TERT） - Zeste同源物2（EZH2）网络的增强剂调节脂质母细胞瘤中的脂质代谢和DNA DNA损伤反应
2. Telomerase Reverse Transcriptase and Peroxisome Proliferator-Activated Receptor γ Co-Activator-1α Cooperate to Protect Cells from DNA Damage and Mitochondrial Dysfunction in Vascular Senescence. [J] . Andrew R Mendelsohn, James W Larrick Rejuvenation research . 2015,第5期

机译：端粒酶逆转录酶和过氧化物酶体增殖物激活的受体γ共激活因子1α协同保护细胞免受DNA损伤和血管衰老中的线粒体功能障碍。
3. Telomerase Reverse Transcriptase and Peroxisome Proliferator-Activated Receptor γ Co-Activator-1α Cooperate to Protect Cells from DNA Damage and Mitochondrial Dysfunction in Vascular Senescence. [J] . Andrew R Mendelsohn, James W Larrick Rejuvenation research . 2015,第5期

机译：端粒酶逆转录酶和过氧化物体增殖物激活受体γ共激活剂-1α合作以保护来自DNA损伤和线粒体功能障碍的细胞免受血管衰老。
4. TRANSCRIPTIONAL REGULATION MECHANISMS OF TELOMERASE REVERSE TRANSCRIPTASE GENE RESPONSIBLE FOR UBIQUITOUS EXPRESSION OF TELOMERASE IN MOUSE [C] . T. Fujiki, Y. Katakura, T. Miura, Annual Meeting of the Japanese Association for Animal Cell Technology . 2003

机译：端粒酶逆转录酶基因的转录调节机制，其对小鼠端粒酶普遍存在的逆转转录酶基因
5. Cell cycle-regulated human DNA helicase B in DNA damage response. [D] . Gu, Jinming. 2005

机译：细胞周期调节的人类DNA解旋酶B在DNA损伤反应中。
6. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses [O] . Kenkichi Masutomi, Richard Possemato, Judy M. Y. Wong, 2005

机译：端粒酶逆转录酶调节染色质状态和DNA损伤反应
7. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses [O] . Masutomi, Kenkichi, Possemato, Richard, Wong, Judy M. Y., 2005

机译：端粒酶逆转录酶调节染色质状态和DNA损伤反应

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses

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