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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cell and plastid division are coordinated through the prereplication factor AtCDT1
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Cell and plastid division are coordinated through the prereplication factor AtCDT1

机译:细胞和质体分裂通过复制因子AtCDT1协调

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摘要

The cell division cycle involves nuclear and cytoplasmic events, namely organelle multiplication and distribution between the daughter cells. Until now, plastid and plant cell division have been considered as independent processes because they can be uncoupled. Here, down-regulation of AtCDT1a and AtCDT1b, members of the prereplication complex, is shown to alter both nuclear DNA replication and plastid division in Arabidopsis thaliana. These data constitute molecular evidence for relationships between the cell-cycle and plastid division. Moreover, the severe developmental defects observed in AtCDT1-RNA interference (RNAi) plants underline the importance of coordinated cell and organelle division for plant growth and morphogenesis.
机译:细胞分裂周期涉及核和细胞质事件,即子细胞之间的细胞器增殖和分布。迄今为止,质体和植物细胞分裂一直被认为是独立的过程,因为它们可以解偶联。在这里,下调AtCDT1a和AtCDT1b,即复制前复合体的成员,可以改变拟南芥中的核DNA复制和质体分裂。这些数据构成了细胞周期与质体分裂之间关系的分子证据。此外,在AtCDT1-RNA干扰(RNAi)植物中观察到的严重发育缺陷强调了协调的细胞和细胞器分裂对于植物生长和形态发生的重要性。

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