...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Altering cannabinoid signaling during development disrupts neuronal activity
【24h】

Altering cannabinoid signaling during development disrupts neuronal activity

机译：在发育过程中改变大麻素信号传导会破坏神经元活动

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In adult cortical tissue, recruitment of GABAergic inhibition prevents the progression of synchronous population discharges to epileptic activity. However, at early developmental stages, GABA is excitatory and thus unable to fulfill this role. Here,we report that retrograde signaling involving endocannabinoids is responsible for the homeostatic control of synaptic transmission and the resulting network patterns in the immature hippocampus. Blockade of cannabinoid type 1 (CB1) receptor led to epileptic discharges, whereas overactivation of CB1 reduced network activity in vivo. Endocannabinoid signaling thus is able to keep population discharge patterns within a narrow physiological time window, balancing between epilepsy on one side and sparse activity on the other, which may result in impaired developmental plasticity. Disturbing this delicate balance during pregnancy in either direction, e.g., with marijuana as a CB1 agonist or with an antagonist marketed as an antiobesity drug, can have profound consequences for brain maturation even in human embryos.
机译：在成人皮质组织中，GABA能抑制的募集阻止了同步的种群放电向癫痫活动的发展。但是，在发育的早期阶段，GABA具有兴奋性，因此无法发挥这一作用。在这里，我们报告涉及内源性大麻素的逆行信号负责突触传递的稳态控制和未成熟海马中的网络模式。大麻素1型（CB1）受体的阻滞导致癫痫放电，而CB1的过度激活降低了体内的网络活性。因此，内源性大麻素信号传导能够将种群放电模式保持在狭窄的生理时间范围内，在一侧的癫痫和另一侧的稀疏活动之间取得平衡，这可能导致发育可塑性受损。怀孕期间在任一方向上扰乱这种微妙的平衡，例如使用大麻作为CB1激动剂或使用市售的抗肥胖药拮抗剂，即使在人类胚胎中也可能对大脑成熟产生深远的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号