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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Fractal intermediates in the self-assembly of silicatein filaments
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Fractal intermediates in the self-assembly of silicatein filaments

机译：硅酸盐长丝自组装中的分形中间体

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摘要

Silicateins are proteins with catalytic, structure-directing activity that are responsible for silica biosynthesis in certain sponges; they are the constituents of macroscopic protein filaments that are found occluded within the silica needles made by Tethya aurantia. Self-assembly of the silicatein monomers and oligomers is shown to form fibrous structures by a mechanism that is fundamentally different from any previously described filament-assembly process. This assembly proceeds through the formation of diffusion-limited, fractally patterned aggregates on the path to filament formation. The driving force for this self-assembly is suggested to be entropic, mediated by the interaction of hydrophobic patches on the surfaces of the silicatein subunits that are not found on highly homologous congeners that do not form filaments. our results are consistent with a model in which silicatein monomers associate into oligomers that are stabilized by intermolecular disulfide bonds. These oligomeric units assemble into a fractal network that subsequently condenses and organizes into a filamentous structure. These results represent a potentially general mechanism for protein fiber self-assembly.
机译：硅酸盐蛋白是具有催化结构导向活性的蛋白质，负责某些海绵中的二氧化硅生物合成。它们是肉眼可见的蛋白质丝的成分，被发现被特提亚·奥兰蒂亚（Tethya aurantia）制造的二氧化硅针头堵塞。硅酸盐单体和低聚物的自组装显示出通过与前述任何长丝组装方法根本不同的机理形成纤维结构。该组装通过在长丝形成的路径上形成扩散受限的，分形图案的聚集体来进行。该自组装的驱动力被认为是熵的，这是由硅酸盐亚基表面上的疏水性斑块的相互作用介导的，而在硅酸盐亚基的亚型表面上，疏水性斑块在不形成细丝的高度同源同源物中没有发现。我们的结果与一个模型相吻合，在该模型中，硅酸盐单体与分子间二硫键稳定的低聚物缔合。这些低聚单元组装成分形网络，该分形网络随后凝结并组织成丝状结构。这些结果代表了蛋白质纤维自组装的潜在通用机制。

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