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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Profile of Diane E. Griffin
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Profile of Diane E. Griffin

机译：黛安·格里芬（Diane E.Griffin）的个人资料

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Reflecting on her career, Diane Griffin admits that she never had a grand plan for her scientific path. When she started graduate school, she did not know what kind of doctorate she wanted. "This was a follow-your-nose career; this was a take-advantage-of-the-opportunities career," she says. Currently Professor of Medicine and Neurology at Johns Hopkins University School of Medicine (Baltimore, MD) and Professor and Alfred and Jill Sommer Chair of the Department of Molecular Microbiology and Immunology at Johns Hopkins Bloomberg School of Public Health, Griffin has made the most of the sometimes serendipitous opportunities that have peppered her life to become one of the leading researchers in infectious virology. Griffin has studied host immune responses to viral infections since she first arrived at Johns Hopkins in 1970. "It's such a fascinating area where both host and invader can determine what the outcome is, whether an animal lives or dies." Her two primary areas of research include neurovirulence in Sindbis virus and immunosuppression induced by human measles virus. In both areas, Griffin's research has revealed many of the mechanisms by which these viruses interact with their host and cause disease. She has received many accolades for her pioneering work, including elections to both the American Academy of Microbiology and the National Academy of Sciences in 2004. She now uses her knowledge of the measles virus to develop new vaccines. In her Inaugural Article in this issue of PNAS, Griffin reports on her latest vaccine design using Sindbis virus particles expressing the measles hemaggluti-nin protein. Her findings highlight the complexity involved in clearing measles virus from the body and may lead to a new vaccine that could be administered to infants in developing countries, where measles still remains a major public health concern.
机译：回顾自己的职业生涯，戴安娜·格里芬（Diane Griffin）坦言，她从未为自己的科学道路制定过宏伟的计划。当她开始读研究生时，她不知道自己想要什么样的博士学位。她说：“这是一个跟随你的鼻子的职业；这是一个抓住机会的职业。”格里芬目前是约翰·霍普金斯大学医学院（巴尔的摩）的医学和神经病学教授，以及约翰·霍普金斯·彭博格公共卫生学院分子微生物学和免疫学系系主任兼教授兼Alfred和Jill Sommer。有时偶然的机会使她成为了传染病病毒学的领先研究者之一，这使她的生活更加活跃。自从格里芬（Griffin）于1970年首次来到约翰·霍普金斯大学（Johns Hopkins）以来，她就一直研究宿主对病毒感染的免疫反应。她的两个主要研究领域包括Sindbis病毒的神经毒性和人麻疹病毒诱导的免疫抑制。在这两个领域，格里芬的研究都揭示了这些病毒与其宿主相互作用并引起疾病的许多机制。她的开创性工作赢得了许多赞誉，包括2004年当选美国微生物学会和美国国家科学院院士。她现在利用对麻疹病毒的了解来开发新疫苗。格里芬（Griffin）在本期PNAS的就职演说中报告了她最新的疫苗设计，该疫苗设计使用了表达麻疹血凝素蛋白的辛德比斯病毒颗粒。她的发现突显了从体内清除麻疹病毒涉及的复杂性，并可能导致可以向发展中国家的婴儿接种新疫苗，而发展中国家的麻疹仍是主要的公共卫生问题。

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