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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation
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Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation

机译：胚胎干细胞分化过程中造血和心脏中胚层的顺序发育

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摘要

The ability to generate a wide spectrum of differentiated cell types from ES cells in culture offers a powerful approach for studying lineage induction and specification and a promising source of progenitors for cell replacement therapy. Although significant efforts are being made to optimize culture conditions for the generation of different cell populations from ES cells, the identification and efficient isolation of specific progenitors for many lineages within these cultures remains a major challenge. By specifically tracking hematopoietic and cardiac development, we demonstrate here that these two lineages arise from distinct mesoderm subpopulations that develop in sequential waves from pre-mesoderm cells. Access to these populations provides a unique approach to isolate and characterize the earliest progenitors of these lineages.
机译：从培养的ES细胞中产生多种分化细胞类型的能力为研究谱系诱导和特异性提供了一种有力的方法，并为细胞替代疗法提供了有希望的祖细胞来源。尽管人们正在作出巨大的努力来优化培养条件，以便从ES细胞中产生不同的细胞群，但是对于这些培养物中许多谱系的特异性祖细胞的鉴定和有效分离仍然是一个重大挑战。通过专门跟踪造血和心脏的发育，我们在这里证明这两个谱系来自不同的中胚层亚群，这些亚群在中胚层前细胞的连续波中发育。接触这些种群提供了一种独特的方法来分离和鉴定这些谱系的最早祖细胞。

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