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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >NO-mediated cytoprotection: Instant adaptation to oxidative stress in bacteria
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NO-mediated cytoprotection: Instant adaptation to oxidative stress in bacteria

机译：NO介导的细胞保护：可即时适应细菌中的氧化应激

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摘要

Numerous sophisticated systems have been described that protect bacteria from increased levels of reactive oxygen species. Although indispensable during prolonged oxidative stress, these response systems depend on newly synthesized proteins, and are hence both time and energy consuming. Here, we describe an "express" cytoprotective system in Bacillus subtilis which depends on nitric oxide (NO). We show that NO immediately protects bacterial cells from reactive oxygen species by two independent mechanisms. NO transiently suppresses the enzymatic reduction of free cysteine that fuels the damaging Fenton reaction. In addition, NO directly reactivates catalase, a major antioxidant enzyme that has been inhibited in vivo by endogenous cysteine. Our data also reveal a critical role for bacterial NO-synthase in adaptation to oxidative stress associated with fast metabolic changes, and suggest a possible role for NO in defending pathogens against immune oxidative attack.
机译：已经描述了许多复杂的系统，它们可以保护细菌免于增加活性氧种类的水平。尽管在长时间的氧化应激中必不可少，但这些响应系统依赖于新合成的蛋白质，因此既耗时又耗能。在这里，我们描述了依赖一氧化氮（NO）的枯草芽孢杆菌中的“表达”细胞保护系统。我们显示NO可以通过两个独立的机制立即保护细菌细胞免受活性氧的影响。 NO会暂时抑制游离半胱氨酸的酶促还原，从而加剧破坏性的Fenton反应。另外，NO直接激活过氧化氢酶，过氧化氢酶是一种主要的抗氧化酶，在体内已被内源性半胱氨酸抑制。我们的数据还揭示了细菌NO合酶在适应与快速代谢变化相关的氧化应激中的关键作用，并暗示了NO在防御病原体抵抗免疫氧化攻击中的可能作用。

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