Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries

Wu XL; Alexander PB; He Y; Kikkawa M; Vogel PD; McKnight SL

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Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries

机译：哺乳动物发芽蛋白组装成具有细胞内纳米电池特性的大单分散颗粒

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摘要

Sprouty proteins act as intracellular inhibitors of receptor tyrosine kinase signaling. Here we show that the mammalian Sprouty2 protein contains an iron-sulfur complex that can exist in an oxidized, reduced, or nitrosylated state. Purified Sprouty2 assembles into large monodisperse spheres containing approximate to 24 polypeptides per particle. Biochemical experiments indicate that the charge state of the iron within Sprouty2 particles may be insulated from ambient intracellular redox. These features offer the possibility that Sprouty2 particles are capable of receiving, maintaining, and dissipating electrical charge in a manner formally equivalent to a battery.

机译：杂散蛋白充当受体酪氨酸激酶信号传导的细胞内抑制剂。在这里，我们显示哺乳动物Sprouty2蛋白包含可以以氧化，还原或亚硝基化状态存在的铁硫复合物。纯化的Sprouty2组装成大的单分散球体，每个颗粒中包含大约24个多肽。生化实验表明，Sprouty2颗粒中铁的电荷状态可能与周围的细胞内氧化还原绝缘。这些功能使Sprouty2颗粒能够以形式上等效于电池的方式接收，保持和耗散电荷。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2005年第39期|p. 14058-14062|共5页
作者
Wu XL; Alexander PB; He Y; Kikkawa M; Vogel PD; McKnight SL;
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作者单位

Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
iron-sulfur; multisubunit; redox; DROSOPHILA; MECHANISM; MIGRATION; CLUSTERS; TRACHEAL; HOMOLOG; ENCODES; COMPLEX; SYSTEMS; SULFUR;

机译：铁硫;多亚基;氧化还原;果蝇;机理;迁移;簇;气管;同源;编码;复合物;系统;硫;

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5. Identification and analysis of mammalian Sprouty proteins [D] . Jarvis, Lesley Ann 2008

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6. Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries [O] . Xinle Wu, Peter B. Alexander, Ying He, 2005

机译：哺乳动物发芽蛋白组装成具有细胞内纳米电池特性的大单分散颗粒
7. Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries [O] . Wu, Xinle, Alexander, Peter B., He, Ying, 2005

机译：哺乳动物发芽蛋白组装成具有细胞内纳米电池特性的大单分散颗粒
8. Intracellular Delivery of Proteins and Nucleic Acids to Mammalian Cells With Invaplex Isolated From Shigella flexneri [R] . Kaminski, R. W. , Turbyfill, K. R. , Oaks, E. V. 2004

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Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries

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