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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Dynamics of sleep-wake cyclicity in developing rats.
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Dynamics of sleep-wake cyclicity in developing rats.

机译：发育中大鼠睡眠-觉醒周期性的动力学。

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摘要

Adult mammals cycle between periods of sleep and wakefulness. Recent assessments of these cycles in humans and other mammals indicate that sleep bout durations exhibit an exponential distribution, whereas wake bout durations exhibit a power-law distribution. Moreover, it was found that wake bout distributions, but not sleep bout distributions, exhibit scale invariance across mammals of different body sizes. Here we test the generalizability of these findings by examining the distributions of sleep and wake bout durations in infant rats between 2 and 21 days of age. In agreement with Lo et al., we find that sleep bout durations exhibit exponential distributions at all ages examined. In contrast, however, wake bout durations also exhibit exponential distributions at the younger ages, with a clear power-law distribution only emerging at the older ages. Further analyses failed to find substantial evidence either of short- or long-term correlations in the data, thus suggesting that the durations of current sleep and wake bouts evolve through time without memory of the durations of preceding bouts. These findings further support the notion that bouts of sleep and wakefulness are regulated independently. Moreover, in light of recent evidence that developmental changes in sleep and wake bouts can be attributed in part to increasing forebrain influences, these findings suggest the possibility of identifying specific neural circuits that modulate the changing complexity of sleep and wake dynamics during development.
机译：成年哺乳动物在睡眠和清醒之间循环。对人类和其他哺乳动物中这些周期的最新评估表明，睡眠发作持续时间呈指数分布，而唤醒发作持续时间呈幂律分布。此外，发现在不同体型的哺乳动物中，尾巴回旋分布而不是睡眠回旋分布表现出尺度不变性。在这里，我们通过检查2至21天大的幼鼠的睡眠和唤醒周期的分布来检验这些发现的一般性。与Lo等人的观点一致，我们发现在所有检查的年龄中，睡眠发作的持续时间都呈指数分布。然而，相比之下，唤醒回合的持续时间在较年轻的年龄也表现出指数分布，只有在较年长的年龄才出现明显的幂律分布。进一步的分析未能找到数据中短期或长期相关性的实质证据，因此表明当前睡眠和唤醒发作的持续时间会随时间变化而没有记忆先前发作的持续时间。这些发现进一步支持了睡眠和清醒的发作是独立调节的观点。此外，根据最近的证据表明，睡眠和苏醒动作的发育变化可部分归因于前脑影响的增加，这些发现表明，有可能识别出特定的神经回路来调节发育过程中睡眠和苏醒动态变化的复杂性。

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