...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Development of spectral and temporal response selectivity in the auditory cortex.
【24h】

Development of spectral and temporal response selectivity in the auditory cortex.

机译：在听觉皮层的光谱和时间响应选择性的发展。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The mechanisms by which hearing selectivity is elaborated and refined in early development are very incompletely determined. In this study, we documented contributions of progressively maturing inhibitory influences on the refinement of spectral and temporal response properties in the primary auditory cortex. Inhibitory receptive fields (IRFs) of infant rat auditory cortical neurons were spectrally far broader and had extended over far longer duration than did those of adults. The selective refinement of IRFs was delayed relative to that of excitatory receptive fields by an approximately 2-week period that corresponded to the critical period for plasticity. Local application of a GABA(A) receptor antagonist revealed that intracortical inhibition contributes to this progressive receptive field maturation for response selectivity in frequency. Conversely, it had no effect on the duration of IRFs or successive-signal cortical response recovery times. The importance of exposure to patterned acoustic inputswas suggested when both spectral and temporal IRF maturation were disrupted in rat pups reared in continuous, moderate-intensity noise. They were subsequently renormalized when animals were returned to standard housing conditions as adults.
机译：在早期发展中完善和完善听力选择性的机制尚未完全确定。在这项研究中，我们记录了逐渐成熟的抑制作用对主要听觉皮层的光谱和时间响应特性的改善的贡献。婴儿大鼠听觉皮层神经元的抑制性感受野（IRFs）在光谱上比成人要宽得多，并且持续时间比成年人更长。相对于兴奋性感受野，IRF的选择性精制被延迟了大约2周的时间，这对应于可塑性的关键时期。 GABA（A）受体拮抗剂的局部应用表明，皮层内抑制有助于这种渐进的受体场成熟，从而在频率上具有选择性。相反，它对IRF的持续时间或连续信号皮质反应的恢复时间没有影响。当在连续，中等强度的噪声中饲养的幼仔中，频谱和时间IRF的成熟都被破坏时，建议暴露于模式化的声音输入中的重要性。随后，当动物成年后回到标准住房条件时，它们会重新正常化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号