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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Nucleoid remodeling by an altered HU protein: Reorganization of the transcription program.
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Nucleoid remodeling by an altered HU protein: Reorganization of the transcription program.

机译：通过改变的HU蛋白进行核样重塑：转录程序的重组。

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摘要

Bacterial nucleoid organization is believed to have minimal influence on the global transcription program. Using an altered bacterial histone-like protein, HUalpha, we show that reorganization of the nucleoid configuration can dynamically modulate the cellular transcription pattern. The mutant protein transformed the loosely packed nucleoid into a densely condensed structure. The nucleoid compaction, coupled with increased global DNA supercoiling, generated radical changes in the morphology, physiology, and metabolism of wild-type K-12 Escherichia coli. Many constitutive housekeeping genes involved in nutrient utilization were repressed, whereas many quiescent genes associated with virulence were activated in the mutant. We propose that, as in eukaryotes, the nucleoid architecture dictates the global transcription profile and, consequently, the behavior pattern in bacteria.
机译：据信细菌核苷组织对全局转录程序影响最小。使用改变的细菌组蛋白样蛋白，HUalpha，我们表明，核苷构型的重组可以动态调节细胞的转录模式。突变蛋白将松散堆积的类核苷酸转化为致密的结构。核苷的紧密结合，加上增加的全球DNA超螺旋，导致野生型K-12大肠杆菌的形态，生理和代谢发生根本变化。许多涉及营养利用的组成型看家基因被抑制，而许多与毒力相关的静态基因在突变体中被激活。我们建议，就像在真核生物中一样，类核苷酸结构决定了全局转录谱，并因此决定了细菌的行为模式。

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