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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Dual targeting is the rule for organellar aminoacyl-tRNA synthetases in Arabidopsis thaliana.
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Dual targeting is the rule for organellar aminoacyl-tRNA synthetases in Arabidopsis thaliana.

机译：双重靶向是拟南芥中细胞器氨酰基-tRNA合成酶的规则。

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摘要

In plants, protein synthesis occurs in the cytosol, mitochondria, and plastids. Each compartment requires a full set of tRNAs and aminoacyl-tRNA synthetases. We have undertaken a systematic analysis of the targeting of organellar aminoacyl-tRNA synthetases in the model plant Arabidopsis thaliana. Dual targeting appeared to be a general rule. Among the 24 identified organellar aminoacyl-tRNA synthetases (aaRSs), 15 (and probably 17) are shared between mitochondria and plastids, and 5 are shared between cytosol and mitochondria (one of these aaRSs being present also in chloroplasts). Only two were shown to be uniquely chloroplastic and none to be uniquely mitochondrial. Moreover, there are no examples where the three aaRS genes originating from the three ancestral genomes still coexist. These results indicate that extensive exchange of aaRSs has occurred during evolution and that many are now shared between two or even three compartments. The findings have important implications for studies of the translation machinery in plants and on protein targeting and gene transfer in general.
机译：在植物中，蛋白质合成发生在细胞质，线粒体和质体中。每个隔室都需要全套的tRNA和氨酰基tRNA合成酶。我们已经对模型植物拟南芥中的细胞器氨酰基-tRNA合成酶的靶向进行了系统分析。双重定位似乎是一个普遍规则。在24种已鉴定的细胞器氨酰基-tRNA合成酶（aaRSs）中，线粒体和质体之间共有15种（可能约为17种），而胞质溶胶和线粒体之间共有5种（其中aaRS也存在于叶绿体中）。仅显示了两个具有独特的叶绿体特性，没有一个具有独特的线粒体特性。此外，没有任何例子表明源自三个祖先基因组的三个aaRS基因仍然共存。这些结果表明，在进化过程中发生了广泛的aaRS交换，并且现在在两个或什至三个区室之间共享许多aaRS。这些发现对于植物翻译机制的研究以及蛋白质靶向和基因转移的总体研究具有重要意义。

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