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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration.
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Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration.

机译：维持成年神经元的固有生长能力可促进脊髓再生。

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摘要

The peripheral axonal branch of primary sensory neurons readily regenerates after peripheral nerve injury, but the central branch, which courses in the dorsal columns of the spinal cord, does not. However, if a peripheral nerve is transected before a spinal cord injury, sensory neurons that course in the dorsal columns will regenerate, presumably because their intrinsic growth capacity is enhanced by the priming peripheral nerve lesion. As the effective priming lesion is made before the spinal cord injury it would clearly have no clinical utility, and unfortunately, a priming lesion made after a spinal cord injury results in an abortive regenerative response. Here, we show that two priming lesions, one made at the time of a spinal cord injury and a second 1 week after a spinal cord injury, in fact, promote dramatic regeneration, within and beyond the lesion. The first lesion, we hypothesize, enhances intrinsic growth capacity, and the second one sustains it, providing a paradigm for promoting CNS regeneration after injury.
机译：周围神经损伤后，初级感觉神经元的周围轴突分支容易再生，但在脊髓背柱中延伸的中央分支却没有。但是，如果在脊髓损伤之前横断了周围神经，则可能在背柱中走动的感觉神经元将再生，这大概是因为原始的周围神经病变增强了它们的内在生长能力。由于有效的引发损伤是在脊髓损伤之前产生的，因此显然没有临床实用性，不幸的是，脊髓损伤之后产生的引发损伤会导致流产的再生反应。在这里，我们显示了两个致病性病变，一个在脊髓损伤时产生，另一个在脊髓损伤后1周产生，实际上促进了病变内外的戏剧性再生。我们假设，第一个病变可增强内在的生长能力，第二个病变可维持内在的生长能力，为促进损伤后CNS再生提供了范例。

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