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Making ATP.

机译:制作ATP。

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摘要

We present a mesoscopic model for ATP synthesis by F(1)F(o) ATPase. The model combines the existing experimental knowledge of the F(1) enzyme into a consistent mathematical model that illuminates how the stages in synthesis are related to the protein structure. For example, the model illuminates how specific interactions between the gamma, epsilon, and alpha(3)beta(3) subunits couple the F(o) motor to events at the catalytic sites. The model also elucidates the origin of ADP inhibition of F(1) in its hydrolysis mode. The methodology we develop for constructing the structure-based model should prove useful in modeling other protein motors.
机译:我们提出由F(1)F(o)ATPase合成ATP的介观模型。该模型将F(1)酶的现有实验知识结合到一个一致的数学模型中,该数学模型阐明了合成阶段如何与蛋白质结构相关。例如,该模型阐明了γ,ε和alpha(3)beta(3)亚基之间的特定相互作用如何将F(o)电机与催化部位的事件偶联。该模型还阐明了ADP抑制F(1)在其水解模式下的起源。我们开发的用于构建基于结构的模型的方法论应被证明对其他蛋白质驱动器建模有用。

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